Department of Life and Environmental Sciences (DiSVA), Marche Polytechnic University, Ancona.
Aquatic Animal Nutrition and Health Research Group, School of Biological Sciences, Plymouth University, UK.
J Clin Gastroenterol. 2018 Nov/Dec;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S50-S56. doi: 10.1097/MCG.0000000000001064.
An increasing number of studies has shown that dietary probiotics exert beneficial health effects in both humans and animals. It is well established that gut microbiota play a pivotal role in regulating host metabolism, and a growing number of studies has elucidated that probiotics positively interfere with gut microbiota. Accumulating evidence shows that probiotics, through their metabolic activity, produce metabolites that in turn contribute to positively affect host physiology. For these reasons, probiotics have shown significant potential as a therapeutic tool for a diversity of diseases, but the mechanisms through which probiotics act has not been fully elucidated yet. The goal of this review was to provide evidence on the effects of probiotics on gut microbiota changes associated with host metabolic variations, specifically focusing on feed intake and lipid and glucose metabolism. In addition, we review probiotic interaction with the gut microbiota. The information collected here will give further insight into the effects of probiotics on the gut microbiota and their action on metabolite release, energy metabolism, and appetite. This information will help to improve knowledge to find better probiotic therapeutic strategies for obesity and eating disorders.
越来越多的研究表明,膳食益生菌对人类和动物都具有有益的健康影响。众所周知,肠道微生物群在调节宿主代谢方面起着关键作用,越来越多的研究阐明了益生菌可以积极干预肠道微生物群。越来越多的证据表明,益生菌通过其代谢活动产生代谢产物,进而有助于积极影响宿主生理学。出于这些原因,益生菌已显示出作为治疗多种疾病的有前途的工具,但益生菌的作用机制尚未完全阐明。本综述的目的是提供有关益生菌对与宿主代谢变化相关的肠道微生物群变化的影响的证据,特别是重点关注饲料摄入以及脂质和葡萄糖代谢。此外,我们还综述了益生菌与肠道微生物群的相互作用。这里收集的信息将进一步深入了解益生菌对肠道微生物群的影响及其对代谢产物释放、能量代谢和食欲的作用。这些信息将有助于提高知识水平,为肥胖和饮食失调找到更好的益生菌治疗策略。