Ghiazza Clément, Tlili Anis, Billard Thierry
Institute of Chemistry and Biochemistry (ICBMS-UMR CNRS 5246), Université de Lyon, Université Lyon 1, CNRS, F-69622 Lyon, France.
CERMEP-In Vivo Imaging, Groupement Hospitalier Est, F-69677 Lyon, France.
Molecules. 2017 May 19;22(5):833. doi: 10.3390/molecules22050833.
Trifluoromethylselenylated compounds are emergent compounds with interesting physicochemical properties that still suffer from a lack of efficient synthetic methods. We recently developed an efficient one-pot strategy to generate in situ CF₃SeCl and use it in various reactions. Herein, we continue our study of the reactivity scope of this preformed reagent. Cross-coupling reactions with aromatic and heteroaromatic boronic acids have been investigated. The expected products have been obtained, using a stoichiometric amount of copper, with moderate yields.
三氟甲基硒化化合物是一类具有有趣物理化学性质的新兴化合物，但仍缺乏有效的合成方法。我们最近开发了一种高效的一锅法策略，用于原位生成CF₃SeCl并将其用于各种反应。在此，我们继续研究这种预制试剂的反应活性范围。我们研究了与芳族和杂芳族硼酸的交叉偶联反应。使用化学计量的铜得到了预期产物，产率适中。
