Li Xujing, Chen Weijuan, Wang Hui, Wei Qun, Ding Xiaodi, Li Wentong
Department of Pathology, Weifang Medical University, Weifang, Shandong 261053, P.R. China.
Department of Pathology, People's Hospital of Shouguang City, Shouguang, Shandong 262700, P.R. China.
Oncol Rep. 2017 Jul;38(1):465-471. doi: 10.3892/or.2017.5650. Epub 2017 May 18.
Duplication in the chromosome 8q24 region is a frequent occurrence in carcinomas. The PVT1 oncogene (PVT1), a long non-coding RNA, is found in this locus. PVT1 amplification is a frequent event in cancers, such as in lymphomas, serous ovarian, colorectal and breast cancers. Ectopic PVT1 expression is related with reduced survival duration in cancer patients. in the present study, we proved that PVT1 is markedly augmented in breast cancer tissues compared with adjacent non-tumorous tissues. Thus, PVT1 is an independent prognostic factor for the survival duration of breast cancer patients. Furthermore, PVT1 is pivotal in regulating p21 expression. In addition, we detected PVT1 DNA in serum and found that circulating PVT1 DNA significantly increased in the serum of breast cancer patients. Compared with PVT1 RNA, DNA is the main form of the PVT1-derived segment. These relevant findings collectively demonstrate that PVT1 plays a pivotal role in breast cancer and is a possible target for novel breast cancer therapies. The detection of circulating PVT1 DNA fragments may be a convenient means to predict the prognosis of breast cancer patients.
8号染色体q24区域的复制在癌症中经常出现。PVT1癌基因（PVT1）是一种长链非编码RNA，位于该位点。PVT1扩增在癌症中是常见事件，如淋巴瘤、浆液性卵巢癌、结直肠癌和乳腺癌。异位PVT1表达与癌症患者生存期缩短有关。在本研究中，我们证明与相邻非肿瘤组织相比，PVT1在乳腺癌组织中显著增加。因此，PVT1是乳腺癌患者生存期的独立预后因素。此外，PVT1在调节p21表达中起关键作用。此外，我们在血清中检测到PVT1 DNA，发现乳腺癌患者血清中循环PVT1 DNA显著增加。与PVT1 RNA相比，DNA是PVT1衍生片段的主要形式。这些相关发现共同表明，PVT1在乳腺癌中起关键作用，是新型乳腺癌治疗的可能靶点。检测循环PVT1 DNA片段可能是预测乳腺癌患者预后的便捷手段。
