Sharonov B P, Lyzlova S N
Department of Biochemistry, Leningrad State University, USSR.
Biochem Int. 1988 Oct;17(4):783-90.
The ability of serum proteins (albumin, immunoglobulin G) and protein antioxidants (ceruloplasmin, superoxide dismutase and transferrin) to react with O2-. and OCl-, was studied. The interaction between serum proteins and OCl- was shown to be non-specific. Ceruloplasmin is the most effective OCl- trapping protein, and it reacts with O2-. with a considerable efficiency. Therefore, ceruloplasmin is supposed to be the main scavenger of toxic oxygen species generated by stimulated neutrophils.
研究了血清蛋白（白蛋白、免疫球蛋白G）和蛋白质抗氧化剂（铜蓝蛋白、超氧化物歧化酶和转铁蛋白）与超氧阴离子和次氯酸根反应的能力。血清蛋白与次氯酸根之间的相互作用是非特异性的。铜蓝蛋白是最有效的次氯酸根捕获蛋白，它与超氧阴离子反应效率相当高。因此，铜蓝蛋白被认为是受刺激的中性粒细胞产生的有毒氧物种的主要清除剂。
