Chan Yvonne Y, Sandlin Samantha K, Kurzrock Eric A, Osborn Stephanie L
Department of Urology, Davis School of Medicine, University of California, Sacramento, CA 95817, USA.
Stem Cell Program, Institute for Regenerative Cures, University of California, Davis Medical Center, Sacramento, CA 95817, USA.
Biomedicines. 2017 Jan 6;5(1):4. doi: 10.3390/biomedicines5010004.
Many pathological processes including neurogenic bladder and malignancy necessitate bladder reconstruction, which is currently performed using intestinal tissue. The use of intestinal tissue, however, subjects patients to metabolic abnormalities, bladder stones, and other long-term sequelae, raising the need for a source of safe and reliable bladder tissue. Advancements in stem cell biology have catapulted stem cells to the center of many current tissue regeneration and bioengineering strategies. This review presents the recent advancements in the use of stem cells in bladder tissue bioengineering.
包括神经源性膀胱和恶性肿瘤在内的许多病理过程都需要进行膀胱重建，目前这是通过使用肠道组织来完成的。然而，使用肠道组织会使患者出现代谢异常、膀胱结石及其他长期后遗症，因此需要一种安全可靠的膀胱组织来源。干细胞生物学的进展已将干细胞推到了当前许多组织再生和生物工程策略的核心位置。本文综述了干细胞在膀胱组织生物工程应用中的最新进展。
