肿瘤免疫中的固有淋巴细胞
Innate Lymphoid Cells in Tumor Immunity.
作者信息
van Beek Jasper J P, Martens Anne W J, Bakdash Ghaith, de Vries I Jolanda M
机构信息
Department of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands.
Department of Medical Oncology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands.
出版信息
Biomedicines. 2016 Feb 25;4(1):7. doi: 10.3390/biomedicines4010007.
Innate lymphoid cells (ILCs) are a group of immune cells of the lymphoid lineage that do not possess antigen specificity. The group includes natural killer (NK) cells, lymphoid tissue inducer (LTi) cells and the recently identified ILC1s, ILC2s and ILC3s. Although the role of NK cells in the context of cancer has been well established, the involvement of other ILC subsets in cancer progression and resistance is just emerging. Here, we review the literature on the role of the different ILC subsets in tumor immunity and discuss its implications for cancer treatment and monitoring.
固有淋巴细胞（ILC）是一群淋巴谱系的免疫细胞，不具备抗原特异性。该群体包括自然杀伤（NK）细胞、淋巴组织诱导（LTi）细胞以及最近发现的ILC1、ILC2和ILC3。尽管NK细胞在癌症背景下的作用已得到充分证实，但其他ILC亚群在癌症进展和耐药性中的作用才刚刚显现。在此，我们综述了关于不同ILC亚群在肿瘤免疫中作用的文献，并讨论其对癌症治疗和监测的意义。
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