Mak Chun Yue, Sin Helena Pui-Yee, Ho Mary, Chan Vesta Cheuk-Ki, Young Alvin Lerrmann, Brelen Marten Erik
Department of Ophthalmology and Visual Sciences, The Prince of Wales Hospital, 1/F, Eye Centre, 30-32 NganShing Street, Shatin, New Territories, Hong Kong.
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 4/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong.
Int Ophthalmol. 2018 Jun;38(3):1329-1332. doi: 10.1007/s10792-017-0555-x. Epub 2017 May 23.
To report a case of bilateral varicella zoster virus (VZV)-associated acute retinal necrosis (ARN) occurring after both eyes sequential cataract surgery in an elderly immunocompromised patient.
Medical records and investigation results of the patient were reviewed.
Patient experienced floaters and blurring of vision in both eyes 4 weeks after her second uncomplicated cataract surgery. Clinical signs of granulomatous keratic precipitates, prominent vitritis, retinitis and vascular thrombosis were noted in both eyes. Aqueous samples from both eyes were positive for VZV. Disease was treated with intravitreal foscarnet bilaterally and 10 days of systemic intravenous acyclovir (10 mg/kg) followed by oral valaciclovir 1 g three times daily. Final visual acuity at 4 months after initial presentation was 20/60 in both eyes with no retinal detachment noted.
Cataract surgery may have been the trigger for bilateral VZV-associated ARN. Immunocompromised patients can develop ARN and require close observation after cataract surgery. This is, to our knowledge, the first report of bilateral ARN following routine cataract surgery.
报告一例老年免疫功能低下患者双眼先后进行白内障手术后发生双侧水痘带状疱疹病毒(VZV)相关性急性视网膜坏死(ARN)的病例。
回顾该患者的病历和检查结果。
患者在第二次无并发症白内障手术后4周出现双眼飞蚊症和视力模糊。双眼均可见肉芽肿性角膜后沉着物、明显的玻璃体炎、视网膜炎和血管血栓形成的临床体征。双眼房水样本VZV检测呈阳性。双侧眼内注射膦甲酸钠,并静脉注射阿昔洛韦(10mg/kg)10天,随后口服伐昔洛韦1g,每日3次进行治疗。初次就诊后4个月时双眼最终视力为20/60,未发现视网膜脱离。
白内障手术可能是双侧VZV相关性ARN的触发因素。免疫功能低下患者白内障手术后可发生ARN,需要密切观察。据我们所知,这是首例常规白内障手术后双侧ARN的报告。