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白内障手术后急性视网膜坏死:1例水痘-带状疱疹病毒再激活及成功治疗病例

Acute retinal necrosis following cataract surgery: a case of VZV reactivation and successful management.

作者信息

Luo Ting, Wang Lu, Zhang Li, Hu Ming-Jue, Zhou Si-Rui, He Xing-Yu, Yang Jun-Feng

机构信息

Department of Ophthalmology, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.

Department of Ophthalmology, The Second People's Hospital of Chengdu, Chengdu, Sichuan, China.

出版信息

BMC Ophthalmol. 2025 Mar 14;25(1):131. doi: 10.1186/s12886-025-03950-y.

Abstract

BACKGROUND

Acute retinal necrosis triggered by routine cataract surgery is a rare condition, which may be overlooked by the clinicians. We report a case of unilateral acute retinal necrosis (ARN) with the onset 4 days after uncomplicated cataract surgery. The patient demonstrates satisfactory outcomes following anti-virus therapy.

CASE PRESENTATION

A 73-year-old male presenting with 1-day history of floaters, eye redness, pain and vision loss in his right eye was referred to our clinic. He had just completed uncomplicated phacoemulsification and posterior chamber intraocular lens implantation in the right eye 5 days ago. He had a history of cutaneous herpes zoster infection at the age of 40. The visual acuity was counting fingers in the right eye at presentation with marked anterior and posterior segment inflammation. ARN was suspected based on fundus findings, including retinal hemorrhage, vessel attenuation and retinal whitening. Following anti-virus therapy, the inflammation and visual acuity improved. Aqueous humor for viral DNA testing using polymerase chain reaction showed positivity to varicella zoster virus (VZV), confirming the diagnosis of VZV associated ARN. The visual acuity improved to 18/20 at one month follow-up examination with no recurrence of inflammation.

CONCLUSIONS

Clinicians should be aware of the possibility of cataract surgery as a triggering event for reactivation of VZV and subsequent ARN. Anti-virus therapy initiated at early phase of the disease may yield satisfactory visual outcomes for the patient. Careful preoperative screening and postoperative monitoring in patients with a history of herpes infection is important.

摘要

背景

常规白内障手术引发的急性视网膜坏死是一种罕见病症,可能会被临床医生忽视。我们报告一例在无并发症白内障手术后4天发病的单侧急性视网膜坏死(ARN)病例。该患者经抗病毒治疗后取得了满意的疗效。

病例介绍

一名73岁男性因右眼出现1天的飞蚊症、眼红、疼痛及视力丧失症状被转诊至我院。他5天前刚刚在右眼完成了无并发症的超声乳化白内障吸除术及后房型人工晶状体植入术。他在40岁时曾有皮肤带状疱疹感染病史。就诊时右眼视力为眼前指数,伴有明显的前段和后段炎症。基于眼底检查结果怀疑为ARN,包括视网膜出血、血管变细及视网膜变白。经抗病毒治疗后,炎症及视力均有所改善。采用聚合酶链反应进行病毒DNA检测的房水样本显示水痘带状疱疹病毒(VZV)呈阳性,确诊为VZV相关性ARN。在1个月的随访检查中,视力提高到18/20,且无炎症复发。

结论

临床医生应意识到白内障手术可能作为VZV再激活及随后ARN的触发事件。在疾病早期开始抗病毒治疗可能为患者带来满意的视力预后。对有疱疹感染病史的患者进行仔细的术前筛查及术后监测很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/11907935/b71956f48681/12886_2025_3950_Fig1_HTML.jpg

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