Zhang Dan, Zhang Yang, Zhu Baoyu, Zhang He, Sun Ye, Sun Chengxun
Electrical Power Research Institute, Jilin Electrical Power Company Limited, Changchun 130021, Jilin, China.
Oncotarget. 2017 Jul 18;8(29):47497-47506. doi: 10.18632/oncotarget.17668.
High-voltage electricity lines are known to generate extremely low-frequency electromagnetic fields (ELF-EMFs). With the process of urbanization, increasing concerns has been focused on the potentially hazardous impacts of ELF-EMF on human health, and the conclusions are controversial. Little is known about the method of prevention against ELF-EMF induced healthy problems. A total of 186 male workers with occupational exposure to high-voltage electricity lines, and 154 male subjects with insignificant exposure as reference control were enrolled in this study. Resveratrol or placebo was given as dietary supplements (500 mg twice daily), and several inflammatory biomarkers and biomarkers of oxidative stress were assessed. Workers who had long-term exposure to high-voltage electricity lines exhibited elevated urinary levels of 8-hydroxy-2-deoxy-guanosine (8-OHdG) and F2-isoprostane, compared to the reference group. Lower plasma nuclear factor kappa B (NF-κB) and interleukin (IL)-6 were observed in exposed workers compared to the reference group. Resveratrol significantly reversed the adverse impacts of ELF-EMF. Stimulated cytokine production by resveratrol was found in exposed workers but not in the reference group. This study supported that occupational and long-term exposure to high-voltage electricity lines has an adverse effect on homeostasis of human body, and resveratrol supplement could be an effective protection strategy against the adverse effects induced by ELF-EMFs.
众所周知，高压电线会产生极低频电磁场（ELF-EMF）。随着城市化进程的推进，人们越来越关注ELF-EMF对人体健康的潜在危害影响，而相关结论存在争议。对于预防ELF-EMF引发健康问题的方法知之甚少。本研究共纳入了186名职业性接触高压电线的男性工人，以及154名接触程度可忽略不计的男性受试者作为对照。给予白藜芦醇或安慰剂作为膳食补充剂（每日两次，每次500毫克），并评估了几种炎症生物标志物和氧化应激生物标志物。与对照组相比，长期接触高压电线的工人尿中8-羟基-2-脱氧鸟苷（8-OHdG）和F2-异前列腺素水平升高。与对照组相比，接触组工人血浆核因子κB（NF-κB）和白细胞介素（IL）-6水平较低。白藜芦醇显著逆转了ELF-EMF的不利影响。在接触组工人中发现白藜芦醇刺激了细胞因子的产生，而对照组未发现。本研究支持职业性长期接触高压电线会对人体稳态产生不利影响，补充白藜芦醇可能是预防ELF-EMF所致不利影响的有效保护策略。
