甲基苯丙胺作用后自由活动大鼠伏隔核神经元活动的改变
Alterations of accumbens neuronal activity in freely moving rats following methamphetamine.
作者信息
Fukuzako H, Nagatomo I, Nomaguchi M, Takenouchi K, Matsumoto K
机构信息
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan.
出版信息
Jpn J Psychiatry Neurol. 1988 Jun;42(2):331-5. doi: 10.1111/j.1440-1819.1988.tb01984.x.
Multiple unit activity in the nucleus accumbens, locomotor activity, and stereotyped behavior were simultaneously recorded in freely moving rats. An intraperitoneal injection of 1.5 mg/kg methamphetamine produced an increase in the firing rate while a decrease in the discharge rate occurred following an administration of 4.5 mg/kg methamphetamine. In addition, the unit activity was positively correlated with the locomotor activity and negatively correlated with the stereotypy score. These results suggest that accumbens neuronal activation during locomotor hyperactivity may partly depend on the feedback from locomotion.
在自由活动的大鼠中同时记录伏隔核的多单位活动、运动活动和刻板行为。腹腔注射1.5mg/kg甲基苯丙胺会使放电率增加，而注射4.5mg/kg甲基苯丙胺后放电率会降低。此外，单位活动与运动活动呈正相关，与刻板行为评分呈负相关。这些结果表明，运动亢进期间伏隔核神经元的激活可能部分取决于来自运动的反馈。
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