Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat.

The injection of (-)3-PPP into the nucleus accumbens, 10 microgram/side, produced a suppression of exploratory locomotor activity without affecting treadmill locomotion. Furthermore, the suppression of exploratory locomotor activity produced by (-)3-PPP was antagonized by the administration of haloperidol, 25-50 micrograms/kg i.p.