Cholerton Brenna, Omidpanah Adam, Madhyastha Tara M, Grabowski Thomas J, Suchy-Dicey Astrid M, Shibata Dean K, Nelson Lonnie A, Verney Steven P, Howard Barbara V, Longstreth William T, Montine Thomas J, Buchwald Dedra
*Department of Pathology, Stanford University, Palo Alto, CA †Institute for Research and Education to Advance Community Health, Washington State University, Seattle, WA ∥College of Nursing, Washington State University, Seattle, WA Departments of ‡Radiology §Neurology, School of Medicine **Epidemiology, School of Public Health, University of Washington, Seattle, WA ††College of Medicine, Washington State University, Seattle, WA ¶Department of Psychology, University of New Mexico, Albuquerque, NM #MedStar Health Research Institute, Hyattsville, MD.
Alzheimer Dis Assoc Disord. 2017 Apr-Jun;31(2):94-100. doi: 10.1097/WAD.0000000000000203.
Estimates of hippocampal volume by magnetic resonance imaging have clinical and cognitive correlations and can assist in early Alzheimer disease diagnosis. However, little is known about the relationship between global or regional brain volumes and cognitive test performance in American Indians.
American Indian participants (N=698; median age, 72 y) recruited for the Cerebrovascular Disease and its Consequences in American Indians study, an ancillary study of the Strong Heart Study cohort, were enrolled. Linear regression models assessed the relationship between magnetic resonance imaging brain volumes (total brain and hippocampi) and cognitive measures of verbal learning and recall, processing speed, verbal fluency, and global cognition.
After controlling for demographic and clinical factors, all volumetric measurements were positively associated with processing speed. Total brain volume was also positively associated with verbal learning, but not with verbal recall. Conversely, left hippocampal volume was associated with both verbal learning and recall. The relationship between hippocampal volume and recall performance was more pronounced among those with lower scores on a global cognitive measure. Controlling for APOE ε4 did not substantively affect the associations.
These results support further investigation into the relationship between structural Alzheimer disease biomarkers, cognition, genetics, and vascular risk factors in aging American Indians.
通过磁共振成像估计海马体体积具有临床和认知相关性，可辅助早期阿尔茨海默病的诊断。然而，关于美国印第安人全脑或局部脑体积与认知测试表现之间的关系，人们了解甚少。
招募了参加美国印第安人脑血管疾病及其后果研究的美国印第安参与者（N = 698；年龄中位数为72岁），该研究是强心脏研究队列的一项辅助研究。线性回归模型评估了磁共振成像脑体积（全脑和海马体）与言语学习和回忆、处理速度、言语流畅性及整体认知的认知测量指标之间的关系。
在控制了人口统计学和临床因素后，所有体积测量值均与处理速度呈正相关。全脑体积也与言语学习呈正相关，但与言语回忆无关。相反，左侧海马体体积与言语学习和回忆均相关。在整体认知测量得分较低的人群中，海马体体积与回忆表现之间的关系更为明显。控制APOE ε4基因并未实质性影响这些关联。
这些结果支持进一步研究衰老的美国印第安人中阿尔茨海默病结构生物标志物、认知、遗传学和血管危险因素之间的关系。
