• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

不稳定型心绞痛的生物标志物及养心汤干预：一项血浆的探索性代谢组学研究

Biomarkers of unstable angina pectoris and yangxin decoction intervention: An exploratory metabonomics study of blood plasma.

作者信息

Yu Xiao-Hong, Sun Jing, Wang Yan, Zhou Ya-Bin

机构信息

Second Department of Cardiovascular, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.

出版信息

Medicine (Baltimore). 2017 May;96(21):e6998. doi: 10.1097/MD.0000000000006998.

DOI:10.1097/MD.0000000000006998
PMID:28538412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5457892/
Abstract

BACKGROUND

This study aimed to explore the related metabolic biomarkers and to observe the effects of Yangxin Decoction (YXD) on plasma metabolism of patients with unstable angina (UA).

METHODS

In total, 10 patients with UA (intervention group) and 10 healthy participants (control group) were recruited for this study from January 2009 to December 2010. Plasma samples from both groups were analyzed using liquid chromatography mass spectrometry (LC-MS). Principle component analysis (PCA) and partial least squares (PLS) were used to explore the correlations between metabolic markers in patients with UA.

RESULTS

The LC-MS results indicated that the serum levels of 5 potential metabolic markers, namely, ceramide, glycocholic acid, allocholic acid, lithocholic acid, and leukotriene (LT) B4, were significantly higher in the intervention group than those in the control group.

CONCLUSION

The results of this study demonstrated potential metabolic markers that can be used to distinguish and diagnose patients with UA.

摘要

背景

本研究旨在探索相关代谢生物标志物，并观察养心汤（YXD）对不稳定型心绞痛（UA）患者血浆代谢的影响。

方法

2009年1月至2010年12月，本研究共招募了10例UA患者（干预组）和10名健康参与者（对照组）。两组的血浆样本均采用液相色谱质谱联用仪（LC-MS）进行分析。主成分分析（PCA）和偏最小二乘法（PLS）用于探索UA患者代谢标志物之间的相关性。

结果

LC-MS结果表明，干预组中5种潜在代谢标志物，即神经酰胺、甘氨胆酸、别胆酸、石胆酸和白三烯（LT）B4的血清水平显著高于对照组。

结论

本研究结果证明了可用于区分和诊断UA患者的潜在代谢标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/e6e0efc50cdc/medi-96-e6998-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/394af681950f/medi-96-e6998-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/b83384f8d41c/medi-96-e6998-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/32cb4ca76e10/medi-96-e6998-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/f65c1e649494/medi-96-e6998-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/955aa56e2920/medi-96-e6998-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/48e925086bdf/medi-96-e6998-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/e6e0efc50cdc/medi-96-e6998-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/394af681950f/medi-96-e6998-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/b83384f8d41c/medi-96-e6998-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/32cb4ca76e10/medi-96-e6998-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/f65c1e649494/medi-96-e6998-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/955aa56e2920/medi-96-e6998-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/48e925086bdf/medi-96-e6998-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dee8/5457892/e6e0efc50cdc/medi-96-e6998-g010.jpg

相似文献

1
Biomarkers of unstable angina pectoris and yangxin decoction intervention: An exploratory metabonomics study of blood plasma.不稳定型心绞痛的生物标志物及养心汤干预：一项血浆的探索性代谢组学研究
Medicine (Baltimore). 2017 May;96(21):e6998. doi: 10.1097/MD.0000000000006998.
2
[Effects of yangxin decoction on metabolomics of patients with unstable angina].养心汤对不稳定型心绞痛患者代谢组学的影响
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Feb;33(2):191-8.
3
Identification of potential plasma biomarkers and metabolic dysfunction for unstable angina pectoris and its complication based on global metabolomics.基于代谢组学的不稳定型心绞痛及其并发症潜在血浆生物标志物和代谢功能障碍的鉴定。
Biosci Rep. 2019 Mar 22;39(3). doi: 10.1042/BSR20181658. Print 2019 Mar 29.
4
Clinical metabolomics analysis of therapeutic mechanism of Tongmai Yangxin Pill on stable angina.通脉养心丸治疗稳定型心绞痛的临床代谢组学分析。
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Nov 15;1100-1101:106-112. doi: 10.1016/j.jchromb.2018.09.038. Epub 2018 Oct 2.
5
Identification of biomarkers for unstable angina by plasma metabolomic profiling.通过血浆代谢组学分析鉴定不稳定型心绞痛的生物标志物
Mol Biosyst. 2013 Dec;9(12):3059-67. doi: 10.1039/c3mb70216b. Epub 2013 Sep 24.
6
[Plasma metabonomic studies on the stable phase chronic obstructive pulmonary disease patients of Fei-qi deficiency syndrome and the Chinese materia medica intervention].[肺气虚证稳定期慢性阻塞性肺疾病患者的血浆代谢组学研究及中药干预]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Dec;31(12):1619-26.
7
Urinary metabolomics study the mechanism of Taohong Siwu Decoction intervention in acute blood stasis model rats based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.基于液相色谱-四极杆飞行时间质谱联用技术的尿代谢组学研究桃红四物汤对急性血瘀模型大鼠的干预机制
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 1;1074-1075:51-60. doi: 10.1016/j.jchromb.2017.12.035. Epub 2018 Jan 2.
8
Analysis of biomarkers and metabolic pathways in patients with unstable angina based on ultra‑high‑performance liquid chromatography‑quadrupole time‑of‑flight mass spectrometry.基于超高效液相色谱-四极杆飞行时间质谱分析不稳定型心绞痛患者的生物标志物和代谢途径。
Mol Med Rep. 2020 Nov;22(5):3862-3872. doi: 10.3892/mmr.2020.11476. Epub 2020 Sep 2.
9
Identification of lithocholic acid and measurement of other bile acids in serum of healthy humans.健康人血清中石胆酸的鉴定及其他胆汁酸的测定
Clin Chem. 1973 Feb;19(2):248-52.
10
Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina.血清代谢组学分析鉴定不稳定型心绞痛的生物标志物。
Biomed Res Int. 2017;2017:7657306. doi: 10.1155/2017/7657306. Epub 2017 May 24.

引用本文的文献

1
Bile Acids and Risk of Adverse Cardiovascular Events and All-Cause Mortality in Patients with Acute Coronary Syndrome.胆汁酸与急性冠状动脉综合征患者不良心血管事件和全因死亡率的关系。
Nutrients. 2024 Apr 5;16(7):1062. doi: 10.3390/nu16071062.
2
Clinical Patterns of Traditional Chinese Medicine for Ischemic Heart Disease Treatment: A Population-Based Cohort Study.基于人群队列研究的中医药治疗缺血性心脏病的临床模式。
Medicina (Kaunas). 2022 Jun 30;58(7):879. doi: 10.3390/medicina58070879.
3
Yangxin Decoction combined acupuncture on blood lipid metabolism in Qi Deficiency and Blood Stasis type of Chest Bi-Syndrome: A protocol of systematic review.

本文引用的文献

1
Salvianolate injection in the treatment of unstable angina pectoris: A systematic review and meta-analysis.丹参多酚酸盐注射液治疗不稳定型心绞痛：一项系统评价与Meta分析
Medicine (Baltimore). 2016 Dec;95(51):e5692. doi: 10.1097/MD.0000000000005692.
2
miR-22 contributes to the pathogenesis of patients with coronary artery disease by targeting MCP-1: An observational study.通过靶向单核细胞趋化蛋白-1，miR-22在冠状动脉疾病患者发病机制中起作用：一项观察性研究。
Medicine (Baltimore). 2016 Aug;95(33):e4418. doi: 10.1097/MD.0000000000004418.
3
Incidence and Risk Factors Associated With Hospitalization for Variant Angina in Korea.
养心汤联合针刺对气虚血瘀型胸痹患者血脂代谢影响的系统评价方案
Medicine (Baltimore). 2020 Aug 21;99(34):e21744. doi: 10.1097/MD.0000000000021744.
韩国变异型心绞痛住院治疗的发病率及相关危险因素。
Medicine (Baltimore). 2016 Mar;95(13):e3237. doi: 10.1097/MD.0000000000003237.
4
Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.代谢组学——系统生物学中的互补领域：关于肥胖症和2型糖尿病的综述
Mol Biosyst. 2015 Jul;11(7):1742-74. doi: 10.1039/c5mb00158g.
5
Susceptibility genes for coronary heart disease and myocardial infarction.冠心病和心肌梗死的易感基因。
Acute Card Care. 2011 Sep;13(3):136-42. doi: 10.3109/17482941.2011.606477.
6
Systems biology approaches and pathway tools for investigating cardiovascular disease.用于研究心血管疾病的系统生物学方法和通路工具。
Mol Biosyst. 2009 Jun;5(6):588-602. doi: 10.1039/b902356a. Epub 2009 Apr 27.
7
Systems biology: Metabonomics.系统生物学：代谢组学。
Nature. 2008 Oct 23;455(7216):1054-6. doi: 10.1038/4551054a.
8
Metabolomics-based methods for early disease diagnostics.基于代谢组学的早期疾病诊断方法。
Expert Rev Mol Diagn. 2008 Sep;8(5):617-33. doi: 10.1586/14737159.8.5.617.
9
Patterns of coronary heart disease mortality over the 20th century in England and Wales: Possible plateaus in the rate of decline.20世纪英格兰和威尔士冠心病死亡率模式：下降速率可能出现平稳期。
BMC Public Health. 2008 May 1;8:148. doi: 10.1186/1471-2458-8-148.
10
Emerging therapies targeting high-density lipoprotein metabolism and reverse cholesterol transport.针对高密度脂蛋白代谢和逆向胆固醇转运的新兴疗法。
Circulation. 2006 Feb 28;113(8):1140-50. doi: 10.1161/CIRCULATIONAHA.105.593855.