Allender Steven, Scarborough Peter, O'Flaherty Martin, Capewell Simon
Division of Public Health and Primary Health Care, University of Oxford, Oxford, UK.
BMC Public Health. 2008 May 1;8:148. doi: 10.1186/1471-2458-8-148.
Coronary heart disease (CHD) rates in England and Wales between 1950 and 2005 were high and reasonably steady until the mid 1970s, when they began to fall. Recent work suggests that the rate of change in some groups has begun to decrease and may be starting to plateau or even reverse.
Data for all deaths between 1931 and 2005 in England and Wales were grouped by year, sex, age at death and contemporaneous ICD code for CHD as cause of death. CHD mortality rates by calendar year and birth cohort were produced for both sexes and rates of change were examined.
The pattern of increased burden of CHD mortality within older age groups has only recently emerged in men, whereas it has been established in women for far longer. CHD mortality rates among younger people showed little variation by birth cohort. For younger women (49 and under), the rate of change in CHD mortality has reversed in the last 20 years, indicating a future plateau and possible reversal of previous improvement in CHD mortality rates. Among younger men the rate of change in CHD mortality has been consistent for the past 15 years indicating that rates in this group have continued to fall steadily.
Although CHD mortality rates continue to drop in older age groups the actual burden of coronary heart disease is increasing due to the ageing of the population. The rate of improvement in CHD mortality appears to be beginning to decline and may even be reversing among younger women.
1950年至2005年间,英格兰和威尔士的冠心病(CHD)发病率一直很高,在20世纪70年代中期之前相当稳定,之后开始下降。最近的研究表明,某些群体的变化率已开始降低,可能正在趋于平稳甚至逆转。
将1931年至2005年间英格兰和威尔士所有死亡数据按年份、性别、死亡年龄以及冠心病作为死亡原因的同期国际疾病分类代码进行分组。计算了各年份和出生队列的男女冠心病死亡率,并研究了变化率。
老年人群体中冠心病死亡率负担增加的模式最近才在男性中出现,而在女性中出现的时间则长得多。年轻人中的冠心病死亡率按出生队列变化不大。对于年轻女性(49岁及以下),冠心病死亡率的变化率在过去20年中已经逆转,这表明未来冠心病死亡率可能趋于平稳并可能逆转之前的改善趋势。在年轻男性中,冠心病死亡率的变化率在过去15年中一直保持一致,表明该群体的死亡率持续稳步下降。
尽管老年人群体中的冠心病死亡率持续下降,但由于人口老龄化,冠心病的实际负担正在增加。冠心病死亡率的改善率似乎开始下降,在年轻女性中甚至可能出现逆转。