Crittendon J J, Shields M B
Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina.
Acta Ophthalmol Suppl (1985). 1988;184:103-6. doi: 10.1111/j.1755-3768.1988.tb02638.x.
Fifty-three patients with the exfoliation syndrome, seen at the Duke University Eye Center, Durham, North Carolina, were characterized by a mean age of 71.3 years, a predilection toward women (38:15), and a marked preponderance of whites to blacks (51:2). There were 31 unilateral and 22 bilateral cases on the initial exam, with glaucoma in 62 of the 75 eyes with exfoliation, as well as 15 of the fellow, non-exfoliation eyes. The incidence of glaucoma is undoubtedly skewed, since the patients were from a glaucoma referral practice. Twenty-four patients were followed from six months to ten years, with a mean of three years, during which time four patients progressed from unilateral to bilateral exfoliation and five more patients acquired glaucoma in eyes with the exfoliation syndrome. The glaucoma associated with the exfoliation syndrome was typically difficult to treat with a high percentage of patients requiring multiple medications or surgical intervention.
在北卡罗来纳州达勒姆市杜克大学眼科中心就诊的53例剥脱综合征患者，平均年龄为71.3岁，女性居多（38例女性比15例男性），白种人明显多于黑种人（51例白种人比2例黑种人）。初次检查时有31例单侧病例和22例双侧病例，75只患有剥脱的眼睛中有62只患有青光眼，另外15只未患剥脱的对侧眼睛也患有青光眼。青光眼的发病率无疑存在偏差，因为这些患者来自青光眼转诊诊所。24例患者随访了6个月至10年，平均3年，在此期间，4例患者从单侧剥脱进展为双侧剥脱，另外5例患有剥脱综合征的眼睛又患上了青光眼。与剥脱综合征相关的青光眼通常难以治疗，很大比例的患者需要多种药物治疗或手术干预。
