对HLA I类免疫肽组和T细胞免疫监视的新见解。
Novel insights into the HLA class I immunopeptidome and T-cell immunosurveillance.
作者信息
Melief Cornelis J M, Kessler Jan H
机构信息
ISA Pharmaceuticals, J.H. Oortweg 19, 2333 CH, Leiden, The Netherlands.
出版信息
Genome Med. 2017 May 24;9(1):44. doi: 10.1186/s13073-017-0439-8.
Abstract
Advances in mass spectrometry have allowed the high-throughput quantitative identification of human leukocyte antigen (HLA) class I ligands, and recent studies have reported on the breadth and diversity of the HLA class I immunopeptidome. These findings have far-reaching implications for immunosurveillance by T cells and translational value for immunotherapy.
摘要
质谱技术的进步使得人类白细胞抗原（HLA）I类配体的高通量定量鉴定成为可能，最近的研究报道了HLA I类免疫肽组的广度和多样性。这些发现对T细胞免疫监测具有深远意义，对免疫治疗也具有转化价值。
Zotero 插件