Le Tu Cam, Yim Chae-Yoon, Park Songhee, Katila Nikita, Yang Inho, Song Myoung Chong, Yoon Yeo Joon, Choi Dong-Young, Choi Hyukjae, Nam Sang-Jip, Fenical William
Department of Chemistry and Nano Science, Ewha Womans University, Seoul 03760, Republic of Korea.
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Bioorg Med Chem Lett. 2017 Jul 15;27(14):3123-3126. doi: 10.1016/j.bmcl.2017.05.035. Epub 2017 May 12.
HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A-C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).
采用高效液相色谱 - 紫外联用技术对海洋细菌糖单孢菌属菌株CNQ - 490的培养液进行分离，得到了两种新的天然产物，洛多吡啶酮B和C（1和2），以及之前报道过的洛多吡啶酮A（3）。通过二维核磁共振光谱数据的解析以及与洛多吡啶酮A（3）的核磁共振数据对比，确定了它们的化学结构。洛多吡啶酮B和C（1和2）含有噻唑和氯喹啉基团，这是这些分子的特征结构。洛多吡啶酮A - C对β - 淀粉样前体蛋白裂解酶1（BACE1）表现出微弱的抑制活性。
