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1型糖尿病与弥漫性系统性硬化症并存——病例报告及文献综述

Coexistence of diabetes mellitus type 1 with diffuse systemic sclerosis - case report and literature review.

作者信息

Wielosz Ewa, Kurowska Maria, Suszek Dorota, Majdan Maria

机构信息

Department of Rheumatology and Connective Tissue Diseases, Medical University, Lublin, Poland.

Department of Endocrynology, Medical University, Lublin, Poland.

出版信息

Reumatologia. 2017;55(2):104-107. doi: 10.5114/reum.2017.67607. Epub 2017 Apr 28.

Abstract

Diabetic sclerodactyly is a frequently recognized skin finding that may occur in patients with diabetes mellitus but coexistence of diabetes and systemic sclerosis is rare. We describe a case of coexistence of type 1 diabetes mellitus and systemic sclerosis in 42-year-old man with the history of Raynaud's phenomenon, progressive diffuse hardening of the skin and sclerodactyly, slowly worsening with time. The medical history included type 1 diabetes since childhood with microvascular complications. The patient presented a typical capillaroscopic scleroderma-like pattern, antinuclear antibodies and sclerotic lesions in gastrointestinal system. Summing up, our case represents the rare coexistence of autoimmune diseases like diabetes mellitus type 1 and systemic sclerosis.

摘要

糖尿病性硬皮病是一种常见的皮肤表现,可发生于糖尿病患者,但糖尿病与系统性硬化症并存的情况较为罕见。我们报告一例42岁男性,患有1型糖尿病和系统性硬化症,有雷诺现象、皮肤进行性弥漫性硬化及硬皮病样改变病史,且病情随时间缓慢加重。病史包括自幼患1型糖尿病并伴有微血管并发症。该患者呈现典型的毛细血管镜下硬皮病样表现、抗核抗体及胃肠道硬化性病变。总之,我们的病例代表了1型糖尿病和系统性硬化症等自身免疫性疾病的罕见并存情况。

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本文引用的文献

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Scleroderma-like disorders.硬皮病样疾病
Autoimmun Rev. 2008 Feb;7(4):331-9. doi: 10.1016/j.autrev.2007.12.004. Epub 2008 Jan 11.
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Cutaneous manifestations of endocrine disorders.内分泌失调的皮肤表现。
Dermatol Nurs. 2001 Jun;13(3):185-6, 189-96; quiz 196, 201-2.

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