Riou G F
Laboratoire de Pharmacologie Clinique et Moléculaire, Institut Gustave Roussy, Villejuif, France.
Cancer Surv. 1988;7(3):441-56.
Although in developed countries the incidence of cervical cancer seems to be declining, it remains a serious health problem. One major concern is the absence of prognostic factors which reliably predict the evolution of early cancers. It is believed that human papillomaviruses are important aetiological factors and their detection in precancerous lesions is a risk factor for malignant transformation. If these viruses seem to have a role in the initiation of cervical cancer, other factors may be necessary to the malignant transformation. Among those, certain proto-oncogenes (c-myc and c-Ha-ras) seem to be involved in the development and progression of cancer. Detection of gene alterations (mutation, deletion, amplification) and gene overexpression in early invasive cancers could be useful to establish a more reliable prognosis. A better surveillance of these high risk patients and a more appropriate treatment could then be selected.
尽管在发达国家宫颈癌的发病率似乎在下降，但它仍然是一个严重的健康问题。一个主要担忧是缺乏能够可靠预测早期癌症发展的预后因素。人们认为人乳头瘤病毒是重要的病因因素，在癌前病变中检测到它们是恶性转化的一个危险因素。如果这些病毒似乎在宫颈癌的起始中起作用，那么恶性转化可能还需要其他因素。其中，某些原癌基因（c-myc和c-Ha-ras）似乎参与了癌症的发生和发展。在早期浸润性癌症中检测基因改变（突变、缺失、扩增）和基因过表达可能有助于建立更可靠的预后。然后可以对这些高危患者进行更好的监测并选择更合适的治疗方法。
