Soleimanizad Reza, Nowroozzadeh Mohammad Hosein, Ziaei Hossein, Pakravan Mohammad, Yaseri Mehdi, Katibeh Marzieh
Department of Ophthalmology, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
Poostchi Ophthalmology Research Center and Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.
J Ophthalmic Vis Res. 2017 Apr-Jun;12(2):141-150. doi: 10.4103/jovr.jovr_111_15.
To assess central corneal thickness (CCT) and its associations in an adult Iranian population.
This was a population-based cross-sectional study of adults aged 40-80 years. Eyes with corneal disorders, previous ocular surgery, or trauma were excluded. All subjects underwent complete ophthalmic examination, general health assessment, laboratory tests, and a detailed interview. CCT was measured with an ultrasonic pachymeter. Intraocular pressure (IOP) was measured with Goldmann applanation tonometry. Except for the report on interocular differences in CCT, only one eye of each subject was used for the rest of statistical analyses.
The mean age (±SD) of the 1203 participants, who had CCT measurements and met inclusion criteria, was 51.8 ± 8.5 years. The mean CCT was 544 ± 35, 564 ± 28, and 544 ± 36 μm in the eyes of the normal, ocular hypertension, and glaucoma groups, respectively ( = 0.025). In participants without glaucoma, the mean interocular difference in CCT was 9 ± 12 μm. CCT was not significantly associated with age, sex, or some select systemic factors (body mass index, diabetes, hypertension, and renal failure). While controlling for age and sex, CCT was greater in individuals with higher IOPs ( < 0.001), larger vertical or horizontal cup-to-disc ratios ( = 0.044, and = 0.025, respectively), and hyperopia ( = 0.009).
In this adult Iranian population, CCT was significantly associated with IOP, cup-to-disc ratio, and the refractive status of eye. CCT outside the normal range of 475-613 μm or with interocular asymmetry greater than 33 μm (6%) should prompt evaluation for potential ocular disorders.
评估伊朗成年人群的中央角膜厚度（CCT）及其相关性。
这是一项基于人群的横断面研究，研究对象为40至80岁的成年人。排除患有角膜疾病、既往有眼部手术史或眼部外伤史的眼睛。所有受试者均接受了全面的眼科检查、一般健康评估、实验室检查和详细访谈。使用超声角膜测厚仪测量CCT。使用Goldmann压平眼压计测量眼压。除了关于CCT眼间差异的报告外，每个受试者仅一只眼睛用于其余的统计分析。
1203名进行了CCT测量并符合纳入标准的参与者的平均年龄（±标准差）为51.8±8.5岁。正常组、高眼压组和青光眼组眼睛的平均CCT分别为544±35、564±28和544±36μm（P = 0.025）。在没有青光眼的参与者中，CCT的平均眼间差异为9±12μm。CCT与年龄、性别或一些特定的全身因素（体重指数、糖尿病、高血压和肾衰竭）无显著相关性。在控制年龄和性别后，眼压较高（P < 0.001）、垂直或水平杯盘比更大（分别为P = 0.044和P = 0.025）以及远视（P = 0.009）的个体CCT更大。
在这一伊朗成年人群中，CCT与眼压、杯盘比和眼睛的屈光状态显著相关。CCT超出475 - 613μm的正常范围或眼间不对称大于33μm（6%）应促使对潜在眼部疾病进行评估。
