Ufa Eye Research Institute, Ufa, Bashkortostan, Russia.
Institute of Clinical and Scientific Ophthalmology and Acupuncture Jonas & Panda, Heidelberg, Germany.
Eye (Lond). 2023 Mar;37(4):705-713. doi: 10.1038/s41433-022-02026-1. Epub 2022 Mar 28.
To assess central corneal thickness (CCT) and its associations in a Russian population.
The population-based Ural Eye and Medical Study included 5899 (80.5%) out of 7328 eligible individuals. As part of an ophthalmological and general examination, CCT was measured by Scheimflug imaging.
The study included 5792 (98.2%) participants (age:58.8 ± 10.6 years;range: 40-94 years) with available bilateral CCT measurements. Mean CCT was larger in Russians than non-Russians (549.5 ± 32.8 µm versus 539.2 ± 33.9 µm; P < 0.001). In multivariable analysis, thicker CCT was associated (regression coefficient r:0.43) with younger age (standardized regression coefficient beta:-0.09; non-standardized regression coefficient B:-0.29;95% confidence interval (CI):-0.39,-0.20; P < 0.001), male sex (beta:0.05; B:3.10; 95%CI:1.18,5.03; P = 0.002), urban region of habitation (beta:0.10; B:6.83; 95%CI:4.61, 9.05; P < 0.001), Russian ethnicity (beta:0.04; B:3.48; 95%CI:1.04, 5.91; P = 0.005), higher level of education (beta:0.04; B:0.97;95%CI:0.29,1.66; P = 0.006), higher serum bilirubin concentration (beta:0.05;B:0.15; 95%CI:0.07,0.23;P < 0.001), lower corneal refractive power (beta:-0.09;B:11.92; 95%CI:-2.50,-1.35; P < 0.001), smaller anterior chamber angle (beta:-0.07;B:-0.38;95%CI:-0.52,-0.24;P < 0.001), higher IOP readings (beta:0.38; B:3.47; 95%CI:3.21,3.73; P < 0.001), and higher rise in IOP readings by medical mydriasis (beta:0.07; B:0.88;95%CI:0.54,1.22;P < 0.001). In that model, CCT was not associated with body height (P = 0.14), previous cataract surgery (P = 0.10), axial length (P = 0.18) or prevalence of glaucoma (P = 0.11). The mean inter-eye difference in CCT was 8.52 ± 13.9 µm (median:6.0;95CI:8.16,8.88). A higher inter-eye CCT difference was associated with older age (beta:0.08; B:0.11;95%CI:0.07,0.15; P = 0.01), lower level of education (beta:-0.04;B:-0.34; 95%CI:-0.60,-0.08; P < 0.001) and status after cataract surgery (beta:0.04; B:2.92;95%CI:1.02,4.83; P = 0.003).
In this ethnically mixed population from Russia with an age of 40+ years, mean CCT (541.7 ± 33.7 µm) was associated with parameters such as younger age, male sex, Russian ethnicity, and higher educational level. These associations may be taken into account when the dependence of IOP readings on CCT are considered. Glaucoma prevalence was unrelated to CCT.
评估俄罗斯人群的中央角膜厚度（CCT）及其相关性。
基于人群的乌拉尔眼与医学研究纳入了 7328 名符合条件的个体中的 5899 名（80.5%）。作为眼科和一般检查的一部分，通过 Scheimflug 成像测量 CCT。
该研究纳入了 5792 名（98.2%）参与者（年龄：58.8±10.6 岁；范围：40-94 岁），他们的双侧 CCT 测量值可用。俄罗斯人与非俄罗斯人相比，CCT 较大（549.5±32.8μm 与 539.2±33.9μm；P<0.001）。在多变量分析中，较薄的 CCT 与较年轻的年龄（回归系数 r：0.43）、男性（回归系数β：0.05；B：3.10；95%置信区间（CI）：0.39，0.20；P<0.001）、城市居住地区（回归系数β：0.10；B：6.83；95%CI：4.61，9.05；P<0.001）、俄罗斯族裔（回归系数β：0.04；B：3.48；95%CI：1.04，5.91；P=0.005）、较高的教育水平（回归系数β：0.04；B：0.97；95%CI：0.29，1.66；P=0.006）、较高的血清胆红素浓度（回归系数β：0.05；B：0.15；95%CI：0.07，0.23；P<0.001）、较低的角膜屈光力（回归系数β：-0.09；B：11.92；95%CI：-2.50，-1.35；P<0.001）、较小的前房角度（回归系数β：-0.07；B：-0.38；95%CI：-0.52，-0.24；P<0.001）、较高的眼压读数（回归系数β：0.38；B：3.47；95%CI：3.21，3.73；P<0.001）以及医学散瞳后眼压升高（回归系数β：0.07；B：0.88；95%CI：0.54，1.22；P<0.001）有关。在该模型中，CCT 与身高（P=0.14）、既往白内障手术（P=0.10）、眼轴长度（P=0.18）或青光眼患病率（P=0.11）无关。CCT 的双眼间平均差异为 8.52±13.9μm（中位数：6.0；95%CI：8.16，8.88）。双眼间 CCT 差异较大与年龄较大（β：0.08；B：0.11；95%CI：0.07，0.15；P=0.01）、教育水平较低（β：-0.04；B：-0.34；95%CI：-0.60，-0.08；P<0.001）和白内障手术后状态（β：0.04；B：2.92；95%CI：1.02，4.83；P=0.003）有关。
在这项来自俄罗斯的混合种族人群中，年龄在 40 岁以上，平均 CCT（541.7±33.7μm）与年龄较小、男性、俄罗斯族裔和较高教育水平等参数相关。在考虑眼压读数对 CCT 的依赖关系时，这些关联可能需要考虑。青光眼患病率与 CCT 无关。
