Laboratorio clinico anatomo-funzionale per la diagnosi e il trattamento del glaucoma e delle malattie neurooftalmologiche, Clinica Oculistica, Department of Neurological Sciences, Ophthalmology, Genetic, University of Genoa, Genoa, Italy.
Eye (Lond). 2012 Nov;26(11):1424-30. doi: 10.1038/eye.2012.179. Epub 2012 Sep 14.
To evaluate whether a difference in central corneal thickness (CCT) between the paired eyes could be associated to worse glaucoma in the thinner cornea eye.
From 16 different glaucoma centres, at least 50 glaucomatous patients were saved on the Italian Glaucoma Register. Eight hundred and sixteen glaucomatous patients were found in the register. CCT, ophthalmoscopic cup/disc ratio, mean deviation (MD), pattern SD (PSD), and intraocular pressure (IOP). The difference (Δ) between the paired eyes was calculated for all the considered parameters and two subgroups were created on the basis of ΔCCT. Because the difference between the two eyes could be positive or negative, the absolute value of Δ was considered for all the measurements. Three different ΔCCT cutoffs were selected: 10, 15, and 20 μm. Student's t-test was used to compare the subgroups.
When the entire group was divided in two subgroups using 20 μm as ΔCCT cutoff, no significant difference was found for ΔIOP (-0.38 ± 2.53 (mean ± SD) mm Hg and -0.07 ± 2.35 mm Hg, respectively) between the two subgroups. Significant (P<0.001) difference was found for ΔMD (6.58 ± 7.30 and 3.14 ± 4.22 dB, respectively), ΔPSD (3.92 ± 4.01 and 2.16 ± 2.57, respectively), and ΔC/D (0.11 ± 0.14 and 0.08 ± 0.11, respectively) between the two subgroups. No significant correlation was found between ΔCCT and the other parameters.
The ΔCCT between the two eyes could be associated to a worse glaucoma in the thinner cornea eye.
评估双眼中央角膜厚度（CCT）差异是否与较薄角膜眼中的青光眼恶化有关。
从 16 个不同的青光眼中心，意大利青光眼登记处至少保存了 50 名青光眼患者。在登记处发现了 816 名青光眼患者。CCT、眼底杯/盘比、平均偏差（MD）、模式标准差（PSD）和眼内压（IOP）。计算了所有考虑参数的双眼差值（Δ），并根据ΔCCT 创建了两个亚组。由于双眼之间的差值可以为正或负，因此考虑了所有测量值的绝对值。选择了 3 个不同的ΔCCT 截止值：10、15 和 20μm。使用学生 t 检验比较亚组。
当整个组用 20μm 作为 ΔCCT 截止值分为两个亚组时，两个亚组之间的 ΔIOP（-0.38 ± 2.53（均值 ± SD）mmHg 和 -0.07 ± 2.35mmHg）无显著差异。ΔMD（6.58 ± 7.30 和 3.14 ± 4.22dB）、ΔPSD（3.92 ± 4.01 和 2.16 ± 2.57）和 ΔC/D（0.11 ± 0.14 和 0.08 ± 0.11）之间存在显著差异（P<0.001）。两个亚组之间 ΔCCT 与其他参数之间没有显著相关性。
双眼之间的 ΔCCT 可能与较薄角膜眼中的青光眼恶化有关。
