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抗双链 DNA 抗体对体外受精-胚胎移植和冻融胚胎移植的影响。

Impacts of Anti-dsDNA Antibody on In Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer.

机构信息

Reproductive Medicine Center for The First Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Reproductive Medicine of Guangdong Province, Guangzhou 510080, China.

出版信息

J Immunol Res. 2017;2017:8596181. doi: 10.1155/2017/8596181. Epub 2017 Apr 28.

DOI:10.1155/2017/8596181
PMID:28540311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5429951/
Abstract

Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+/anti-dsDNA- group), and 121 women with negative ANA and anti-dsDNA (ANA-/anti-dsDNA- group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enrolled in the hormone replacement therapy frozen-thawed embryo transfer (HRT-TET) cycle. We compared basic characters and IVF outcomes among three groups in fresh embryo transfer and frozen-thawed embryo transfer cycle, respectively. The number of retrieved oocytes, available embryos, and high-quality embryos in the ANA+/anti-dsDNA+ group was lower than those in the other two groups in the fresh embryo transfer cycle. The rates of fertilization, implantation, and clinical pregnancy in the ANA+/anti-dsDNA+ group were the lowest, while the early miscarriage rate was the highest in the ANA+/anti-dsDNA+ group both in the fresh embryo transfer cycle and in the frozen-thawed embryo transfer cycle. Our data suggested that anti-dsDNA antibody may be the essential marker for defective oocytes or embryos in infertile women with any type of ANA.

摘要

我们的目的是探讨抗双链 DNA 抗体（该抗体已被证实可进入活细胞并诱导细胞凋亡）是否会对生殖结局产生不利影响。本研究共纳入 259 例行体外受精-胚胎移植（IVF-ET）周期的女性，其中抗核抗体（ANA）阳性且抗双链 DNA 抗体（anti-dsDNA）阳性的患者 52 例（ANA+/anti-dsDNA+组），ANA 阳性且 anti-dsDNA 阴性的患者 86 例（ANA+/anti-dsDNA-组），ANA 阴性且 anti-dsDNA 阴性的患者 121 例（ANA-/anti-dsDNA-组）。将其中 259 例 IVF-ET 周期的患者中未妊娠的 136 例纳入激素替代治疗冻融胚胎移植（HRT-TET）周期。我们比较了 3 组患者在新鲜胚胎移植和冻融胚胎移植周期中的基本特征和 IVF 结局。在新鲜胚胎移植周期中，ANA+/anti-dsDNA+组的获卵数、可利用胚胎数和优质胚胎数均低于其他两组。ANA+/anti-dsDNA+组的受精率、种植率和临床妊娠率均最低，而早期流产率在新鲜胚胎移植周期和冻融胚胎移植周期中均最高。我们的数据表明，抗双链 DNA 抗体可能是 ANA 阳性的不孕女性中卵母细胞或胚胎缺陷的重要标志物。

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本文引用的文献

1
A further exploration of the impact of antinuclear antibodies on in vitro fertilization-embryo transfer outcome.进一步探讨抗核抗体对体外受精-胚胎移植结局的影响。
Am J Reprod Immunol. 2013 Sep;70(3):221-9. doi: 10.1111/aji.12111. Epub 2013 Mar 11.
2
Antinuclear antibodies predicts a poor IVF-ET outcome: impaired egg and embryo development and reduced pregnancy rate.抗核抗体预示着 IVF-ET 结局不佳：卵子和胚胎发育受损，妊娠率降低。
Immunol Invest. 2012;41(5):458-68. doi: 10.3109/08820139.2012.660266. Epub 2012 Mar 19.
3
Antinuclear autoantibodies in women with recurrent pregnancy loss.抗核抗体在复发性流产妇女中的作用。
Am J Reprod Immunol. 2010 Dec;64(6):384-92. doi: 10.1111/j.1600-0897.2010.00863.x.
4
Antinuclear antibodies and endometriosis.
Int J Gynaecol Obstet. 2006 Jun;93(3):262-3. doi: 10.1016/j.ijgo.2006.03.005. Epub 2006 May 19.
5
Chromosomal disorders and nuclear and cell destruction in cleaving human embryos.人类分裂期胚胎中的染色体疾病以及细胞核和细胞破坏
Int J Dev Biol. 2005;49(4):409-16. doi: 10.1387/ijdb.041909sd.
6
Nuclear localizing anti-DNA antibodies enter cells via caveoli and modulate expression of caveolin and p53.核定位抗DNA抗体通过小窝进入细胞，并调节小窝蛋白和p53的表达。
J Autoimmun. 2005 Mar;24(2):145-51. doi: 10.1016/j.jaut.2004.11.008.
7
Antinuclear antibody reduces the pregnancy rate in the first IVF-ET treatment cycle but not the cumulative pregnancy rate without specific medication.抗核抗体在首次体外受精-胚胎移植治疗周期中会降低妊娠率，但在没有特定药物治疗的情况下不会降低累积妊娠率。
Am J Reprod Immunol. 2003 Oct;50(4):363-7. doi: 10.1034/j.1600-0897.2003.00088.x.
8
Antigenic triggers and molecular targets for anti-double-stranded DNA antibodies.抗双链DNA抗体的抗原触发因素及分子靶点
Lupus. 2002;11(12):865-71. doi: 10.1191/0961203302lu308rr.
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Genetic regulation of preimplantation embryo survival.
Int Rev Cytol. 2001;210:1-37. doi: 10.1016/s0074-7696(01)10002-1.
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Monoclonal anti-double stranded DNA antibody is a leucocyte-binding protein to up-regulate interleukin-8 gene expression and elicit apoptosis of normal human polymorphonuclear neutrophils.单克隆抗双链DNA抗体是一种白细胞结合蛋白，可上调白细胞介素-8基因表达并引发正常人多形核中性粒细胞的凋亡。
Rheumatology (Oxford). 2001 Aug;40(8):851-8. doi: 10.1093/rheumatology/40.8.851.