• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

结核性脑膜炎被误诊为单纯疱疹病毒1型脑炎且采用FilmArray综合征聚合酶链反应检测板导致诊断延迟

Delayed Diagnosis of Tuberculous Meningitis Misdiagnosed as Herpes Simplex Virus-1 Encephalitis With the FilmArray Syndromic Polymerase Chain Reaction Panel.

作者信息

Gomez Carlos A, Pinsky Benjamin A, Liu Anne, Banaei Niaz

机构信息

Division of Infectious Diseases and Geographic Medicine, Department of Medicine.

Department of Pathology, and.

出版信息

Open Forum Infect Dis. 2016 Dec 7;4(1):ofw245. doi: 10.1093/ofid/ofw245. eCollection 2017 Winter.

DOI:10.1093/ofid/ofw245
PMID:28540320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5437853/
Abstract

The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encephalitis with the FilmArray ME panel. Strategies to mitigate erroneous results are discussed.

摘要

FilmArray脑膜炎/脑炎（ME）检测板是一种用于诊断急性脑膜炎和脑炎的新型综合征核酸扩增检测方法。关于其性能的新数据令人担忧其可能出现假阳性结果。我们报告一例结核性脑膜炎被FilmArray ME检测板误诊为单纯疱疹病毒1型脑炎的病例。并讨论了减少错误结果的策略。

相似文献

1
Delayed Diagnosis of Tuberculous Meningitis Misdiagnosed as Herpes Simplex Virus-1 Encephalitis With the FilmArray Syndromic Polymerase Chain Reaction Panel.结核性脑膜炎被误诊为单纯疱疹病毒1型脑炎且采用FilmArray综合征聚合酶链反应检测板导致诊断延迟
Open Forum Infect Dis. 2016 Dec 7;4(1):ofw245. doi: 10.1093/ofid/ofw245. eCollection 2017 Winter.
2
Differential Performance of the FilmArray Meningitis/Encephalitis Assay To Detect Bacterial and Viral Pathogens in Both Pediatric and Adult Populations.儿童和成人患者中 FilmArray 脑膜炎/脑炎检测试剂盒对细菌性和病毒性病原体检测性能的差异。
Microbiol Spectr. 2022 Apr 27;10(2):e0277421. doi: 10.1128/spectrum.02774-21. Epub 2022 Apr 11.
3
Use of the FilmArray® Meningitis/Encephalitis panel to detect pathogenic microorganisms in cerebrospinal fluid specimens: a single-center retrospective study.应用 FilmArray® 脑膜炎/脑炎检测 panel 检测脑脊液标本中的病原体：一项单中心回顾性研究。
J Int Med Res. 2022 Oct;50(10):3000605221129561. doi: 10.1177/03000605221129561.
4
Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis.采用简单的样本选择策略，在实验室常规中实施 FilmArray ME 检测 panel，用于诊断脑膜炎和脑炎。
BMC Infect Dis. 2020 Feb 22;20(1):170. doi: 10.1186/s12879-020-4904-4.
5
Diagnostic test accuracy of the BioFire® FilmArray® meningitis/encephalitis panel: a systematic review and meta-analysis.BioFire® FilmArray® 脑膜炎/脑炎检测试剂盒的诊断试验准确性：系统评价和荟萃分析。
Clin Microbiol Infect. 2020 Mar;26(3):281-290. doi: 10.1016/j.cmi.2019.11.016. Epub 2019 Nov 21.
6
Assessment of the FilmArray ME panel in 4199 consecutively tested cerebrospinal fluid samples.评估 FilmArray ME 试剂盒在 4199 份连续检测的脑脊液样本中的表现。
Clin Microbiol Infect. 2022 Jan;28(1):79-84. doi: 10.1016/j.cmi.2021.05.017. Epub 2021 May 17.
7
A Tertiary Care Center's Experience with Novel Molecular Meningitis/Encephalitis Diagnostics and Implementation with Antimicrobial Stewardship.一家三级医疗中心在新型分子性脑膜炎/脑炎诊断及抗菌药物管理实施方面的经验
Mil Med. 2018 Jan 1;183(1-2):e24-e27. doi: 10.1093/milmed/usx025.
8
Evaluation of the QIAstat-Dx Meningitis/Encephalitis Panel, a multiplex PCR platform for the detection of community-acquired meningoencephalitis.评价 QIAstat-Dx 脑膜炎/脑炎检测试剂盒，一种用于检测社区获得性脑脊髓炎的多重 PCR 平台。
J Clin Microbiol. 2023 Oct 24;61(10):e0042623. doi: 10.1128/jcm.00426-23. Epub 2023 Sep 13.
9
Usefulness of the FilmArray meningitis/encephalitis (M/E) panel for the diagnosis of infectious meningitis and encephalitis in Taiwan.用于诊断台湾地区感染性脑膜炎和脑炎的 FilmArray 脑膜炎/脑炎（M/E）检测试剂盒的实用性。
J Microbiol Immunol Infect. 2019 Oct;52(5):760-768. doi: 10.1016/j.jmii.2019.04.005. Epub 2019 Apr 30.
10
Evaluation of a Commercial Multiplex Molecular Panel for Diagnosis of Infectious Meningitis and Encephalitis.商业多重分子面板用于诊断感染性脑膜炎和脑炎的评估。
J Clin Microbiol. 2018 Mar 26;56(4). doi: 10.1128/JCM.01927-17. Print 2018 Apr.

引用本文的文献

1
A Machine Learning Approach for Identifying People With Neuroinfectious Diseases in Electronic Health Records: Algorithm Development and Validation.一种用于在电子健康记录中识别神经感染性疾病患者的机器学习方法：算法开发与验证
JMIR Med Inform. 2025 Aug 29;13:e63157. doi: 10.2196/63157.
2
Evaluation of pathogen from the FilmArray meningitis/encephalitis panel and recommendations on atypical findings.FilmArray脑膜炎/脑炎检测板病原体评估及非典型结果的建议
Arq Neuropsiquiatr. 2024 Jan;82(1):1-8. doi: 10.1055/s-0044-1779035. Epub 2024 Feb 5.
3
The Contribution of Multiplex Polymerase Chain Reaction in the Diagnosis of Central Nervous System Infections in Intensive Care Units.多重聚合酶链反应在重症监护病房中枢神经系统感染诊断中的作用
Cureus. 2023 Feb 22;15(2):e35338. doi: 10.7759/cureus.35338. eCollection 2023 Feb.
4
Comparison of Analytical Sensitivity (Limit of Detection) of Xpert MTB/RIF and Xpert MTB/RIF Ultra for Non-Sputum Specimens.Xpert MTB/RIF和Xpert MTB/RIF Ultra对非痰液标本的分析灵敏度（检测限）比较
Pathogens. 2023 Jan 18;12(2):157. doi: 10.3390/pathogens12020157.
5
Differential Performance of the FilmArray Meningitis/Encephalitis Assay To Detect Bacterial and Viral Pathogens in Both Pediatric and Adult Populations.儿童和成人患者中 FilmArray 脑膜炎/脑炎检测试剂盒对细菌性和病毒性病原体检测性能的差异。
Microbiol Spectr. 2022 Apr 27;10(2):e0277421. doi: 10.1128/spectrum.02774-21. Epub 2022 Apr 11.
6
APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy.亚太肝脏研究学会关于免疫抑制治疗相关乙型肝炎病毒再激活的临床实践指南。
Hepatol Int. 2021 Oct;15(5):1031-1048. doi: 10.1007/s12072-021-10239-x. Epub 2021 Aug 24.
7
The Need for Dedicated Microbiology Leadership in the Clinical Microbiology Laboratory.临床微生物实验室需要微生物学专业领导力。
J Clin Microbiol. 2021 Jul 19;59(8):e0154919. doi: 10.1128/JCM.01549-19.
8
Unusual presentation of meningococcal meningitis in the elderly and utility of CSF PCR testing.老年人群中脑膜炎球菌性脑膜炎的不典型表现及脑脊液聚合酶链反应检测的效用
Access Microbiol. 2020 Aug 12;2(10):acmi000158. doi: 10.1099/acmi.0.000158. eCollection 2020.
9
Rapid Diagnostic Tests for Meningitis and Encephalitis-BioFire.脑膜炎和脑炎的快速诊断检测-生物火。
Pediatr Emerg Care. 2020 Aug;36(8):397-401. doi: 10.1097/PEC.0000000000002180.
10
Utilization, Yield, and Accuracy of the FilmArray Meningitis/Encephalitis Panel with Diagnostic Stewardship and Testing Algorithm.FilmArray脑膜炎/脑炎检测板在诊断管理与检测算法下的利用率、阳性率及准确性
J Clin Microbiol. 2020 Aug 24;58(9). doi: 10.1128/JCM.00311-20.

本文引用的文献

1
Multiplexed Molecular Diagnostics for Respiratory, Gastrointestinal, and Central Nervous System Infections.用于呼吸道、胃肠道和中枢神经系统感染的多重分子诊断方法
Clin Infect Dis. 2016 Nov 15;63(10):1361-1367. doi: 10.1093/cid/ciw494. Epub 2016 Jul 20.
2
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens.BioFire FilmArray脑膜炎/脑炎检测板用于脑脊液标本中细菌、病毒和酵母菌检测的多中心评估
J Clin Microbiol. 2016 Sep;54(9):2251-61. doi: 10.1128/JCM.00730-16. Epub 2016 Jun 22.
3
Evaluation of 2 multiplex real-time PCR assays for the detection of HSV-1/2 and Varicella zoster virus directly from clinical samples.评估两种多重实时荧光定量PCR检测方法直接从临床样本中检测单纯疱疹病毒1/2型和水痘带状疱疹病毒的效果。
Diagn Microbiol Infect Dis. 2015 Mar;81(3):169-70. doi: 10.1016/j.diagmicrobio.2014.11.012. Epub 2014 Dec 3.
4
Comparison of the Simplexa HSV1 & 2 Direct kit and laboratory-developed real-time PCR assays for herpes simplex virus detection.单纯疱疹病毒 1 & 2 直接试剂盒与实验室开发的实时 PCR 检测法用于单纯疱疹病毒检测的比较。
J Clin Virol. 2015 Jan;62:103-5. doi: 10.1016/j.jcv.2014.11.003. Epub 2014 Nov 8.
5
Herpes simplex encephalitis in patients with cancer.癌症患者单纯疱疹病毒性脑炎。
J Neurooncol. 2011 Nov;105(2):415-21. doi: 10.1007/s11060-011-0609-2. Epub 2011 Jun 3.
6
Comparison of single-copy and multicopy real-time PCR targets for detection of Mycobacterium tuberculosis in paraffin-embedded tissue.比较单拷贝和多拷贝实时 PCR 靶标在石蜡包埋组织中检测结核分枝杆菌。
J Clin Microbiol. 2010 Jul;48(7):2569-70. doi: 10.1128/JCM.02449-09. Epub 2010 May 12.
7
Lack of cerebrospinal fluid pleocytosis in young infants with enterovirus infections of the central nervous system.中枢神经系统感染肠道病毒的幼儿脑脊液中无细胞增多现象。
Pediatr Emerg Care. 2010 Feb;26(2):77-81. doi: 10.1097/PEC.0b013e3181ce2fad.
8
The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America.《脑炎的管理：美国传染病学会临床实践指南》
Clin Infect Dis. 2008 Aug 1;47(3):303-27. doi: 10.1086/589747.
9
Use of PCR for the diagnosis of herpesvirus infections of the central nervous system.聚合酶链反应用于诊断中枢神经系统的疱疹病毒感染。
J Clin Virol. 2002 Jul;25 Suppl 1:S5-11. doi: 10.1016/s1386-6532(02)00028-8.
10
Prospective analysis of 61 cases of enteroviral meningitis: interest of systematic genome detection in cerebrospinal fluid irrespective of cytologic examination results.61例肠道病毒性脑膜炎的前瞻性分析：无论脑脊液细胞学检查结果如何，脑脊液中系统基因组检测的意义
J Clin Virol. 2001 Apr;21(1):29-35. doi: 10.1016/s1386-6532(00)00176-1.