Xu Xiaohe, Zhang Na, Brown Gilbert M, Thundat Thomas G, Ji Hai-Feng
Department of Chemistry, Drexel University, Philadelphia, PA, 19104, USA.
Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
Appl Biochem Biotechnol. 2017 Oct;183(2):555-565. doi: 10.1007/s12010-017-2511-7. Epub 2017 May 24.
A microcantilever was modified with a self-assembled monolayer (SAM) of L-cysteine for the sensitively and selectively response to Cu(II) ions in aqueous solution. The microcantilever undergoes bending due to sorption of Cu(II) ions. The interaction of Cu(II) ions with the L-cysteine on the cantilever is diffusion controlled and does not follow a simple Langmuir adsorption model. A concentration of 10 M Cu(II) was detected in a fluid cell using this technology. Other cations, such as Ni, Zn, Pb, Cd, Ca, K, and Na, did not respond with a significant deflection, indicating that this L-cysteine-modified cantilever responded selectively and sensitively to Cu(II).
用L-半胱氨酸自组装单分子层（SAM）修饰微悬臂梁，以实现对水溶液中Cu(II)离子的灵敏且选择性响应。由于Cu(II)离子的吸附，微悬臂梁会发生弯曲。Cu(II)离子与悬臂梁上L-半胱氨酸的相互作用受扩散控制，并不遵循简单的朗缪尔吸附模型。使用该技术在流体池中检测到了浓度为10 M的Cu(II)。其他阳离子，如Ni、Zn、Pb、Cd、Ca、K和Na，未引起明显的偏转响应，这表明这种L-半胱氨酸修饰的悬臂梁对Cu(II)具有选择性和灵敏的响应。
