一种用于将芳基和乙烯基亲核试剂加成到马来酰亚胺上的脱除导向基团方法。
A deciduous directing group approach for the addition of aryl and vinyl nucleophiles to maleimides.
作者信息
Bettadapur Kiran R, Lanke Veeranjaneyulu, Prabhu Kandikere Ramaiah
机构信息
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India.
出版信息
Chem Commun (Camb). 2017 Jun 6;53(46):6251-6254. doi: 10.1039/c7cc02392h.
PMID:28540938
Abstract
A Rh(iii)-catalyzed C-H activation followed by conjugate addition to maleimides, using carboxylic acid as a traceless/deciduous directing group, to formally furnish a C-C bond is presented. For the first time, derivatives of acrylic acid have been shown as surrogates for the unstable and expensive alkenyl boronic acids.
摘要
本文介绍了一种铑（III）催化的C-H活化反应，该反应以羧酸作为无痕/可脱除导向基团，随后与马来酰亚胺进行共轭加成，从而正式构建一个C-C键。首次证明丙烯酸衍生物可作为不稳定且昂贵的烯基硼酸的替代物。
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