尿酸、别嘌呤醇和氧嘌呤醇对髓过氧化物酶衍生的氧化剂次氯酸的作用。
Action of uric acid, allopurinol and oxypurinol on the myeloperoxidase-derived oxidant hypochlorous acid.
作者信息
Grootveld M, Halliwell B, Moorhouse C P
机构信息
Department of Biochemistry, King's College (KQC), Strand Campus, London, UK.
出版信息
Free Radic Res Commun. 1987;4(2):69-76. doi: 10.3109/10715768709088090.
PMID:2854102
Abstract
Both oxypurinol and uric acid react with the myeloperoxidase-derived oxidant hypochlorous acid at physiological pH, and they can protect the elastase-inhibitory capacity of human alpha 1-antiprotease against inactivation by hypochlorous acid. Allopurinol does not protect alpha 1-antiprotease, possibly because the redox potential of allopurinol at physiological pH is too positive to permit oxidation by hypochlorous acid.
摘要
在生理pH值下，氧嘌呤醇和尿酸均可与髓过氧化物酶衍生的氧化剂次氯酸发生反应，并且它们能够保护人α1 -抗蛋白酶的弹性蛋白酶抑制能力不被次氯酸灭活。别嘌呤醇不能保护α1 -抗蛋白酶，这可能是因为在生理pH值下别嘌呤醇的氧化还原电位过于正值，以至于不能被次氯酸氧化。
Zotero 插件