Stote R M, Smith L H, Dubb J W, Moyer T P, Alexander F, Roth J L
Ann Intern Med. 1980 Mar;92(3):384-5. doi: 10.7326/0003-4819-92-3-384.
A patient with regional enteritis and recurrent uric acid nephrolithiasis was treated with allopurinol. While on 600 mg of allopurinol daily, she began to pass many small, soft, yellow stones. Analysis of the stones by liquid chromatographic and gas chromatograph/mass spectrometric techniques revealed that their major constituent was oxypurinol, a metabolite of allopurinol. Metabolic studies of the patient indicated that increasing doses of allopurinol were associated with increases in xanthine and oxypurinol excretion, while uric acid excretion was not reduced. This case illustrates a complication of high-dose allopurinol therapy in the treatment of uric acid nephrolithiasis.
一名患有局限性肠炎和复发性尿酸肾结石的患者接受了别嘌醇治疗。在每日服用600毫克别嘌醇期间，她开始排出许多小的、柔软的黄色结石。通过液相色谱和气相色谱/质谱技术对结石进行分析，结果显示其主要成分是别嘌醇的代谢产物氧嘌呤醇。对该患者的代谢研究表明，别嘌醇剂量增加与黄嘌呤和氧嘌呤醇排泄增加相关，而尿酸排泄并未减少。该病例说明了高剂量别嘌醇治疗尿酸肾结石时的一种并发症。
