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认知康复和暴露/分类治疗(CREST)治疗老年人囤积症的随机临床试验。

Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) for Hoarding Disorder in Older Adults: A Randomized Clinical Trial.

机构信息

3350 La Jolla Village Drive, 116B, San Diego, CA 92161.

Mental Health Care Line, VA San Diego Healthcare System, San Diego, California, USA.

出版信息

J Clin Psychiatry. 2018 Mar/Apr;79(2). doi: 10.4088/JCP.16m11072.

Abstract

OBJECTIVE

To compare the efficacy of Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) with geriatric case management (CM) in a sample of older adults meeting DSM-5 diagnostic criteria for hoarding disorder (HD).

METHODS

Fifty-eight older adults with HD were enrolled in a randomized controlled trial between December 2011 and March 2014. Thirty-one participants received CREST, and 27 participants received CM. Both interventions consisted of 26 individual sessions over a period of 6 months and included several home visits by the study therapists (CREST) or nurses (CM). The Saving Inventory-Revised (SI-R) and the UCLA Hoarding Severity Scale (UHSS) were the main outcome measures.

RESULTS

Participants in the CREST condition had significantly greater improvement on the SI-R than participants in the CM group (group × time interaction: β = 3.95, SE = 1.81, P = .029), with participants who completed the CREST condition averaging a 38% decrease in symptoms and participants who completed the CM condition averaging a 25% decrease in symptoms. In contrast, there was not a significant group × time interaction effect on the UHSS (β = 1.23, SE = 0.84, P = .144), although participants did report greater improvement in symptoms in the CREST condition (35%) than in the CM condition (24%). Treatment gains were maintained at 6-month follow-up.

CONCLUSIONS

CREST appears to be an efficacious treatment compared to CM for older adults, but CM also showed meaningful benefits.

TRIAL REGISTRATION

ClinicalTrials.gov identifier: NCT01227057​.

摘要

目的

在符合 DSM-5 囤积障碍(HD)诊断标准的老年患者样本中,比较认知康复和暴露/分类治疗(CREST)与老年病例管理(CM)的疗效。

方法

2011 年 12 月至 2014 年 3 月,58 名老年 HD 患者参加了一项随机对照试验。31 名参与者接受 CREST,27 名参与者接受 CM。两种干预措施均包括 6 个月内进行 26 次个体治疗,包括研究治疗师(CREST)或护士(CM)的几次家访。主要结局测量指标是修订后的储蓄清单(SI-R)和加州大学洛杉矶分校囤积严重程度量表(UHSS)。

结果

与 CM 组相比,接受 CREST 治疗的参与者在 SI-R 上的改善更为显著(组×时间交互作用:β=3.95,SE=1.81,P=0.029),完成 CREST 治疗的参与者症状平均减轻 38%,完成 CM 治疗的参与者症状平均减轻 25%。相比之下,在 UHSS 上,组×时间交互作用无显著差异(β=1.23,SE=0.84,P=0.144),尽管参与者在 CREST 治疗组报告的症状改善(35%)比在 CM 治疗组(24%)更大。治疗效果在 6 个月的随访中得以维持。

结论

与 CM 相比,CREST 似乎是一种有效的治疗方法,但 CM 也显示出了有意义的益处。

试验注册

ClinicalTrials.gov 标识符:NCT01227057。

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