Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Cariology and Operative Dentistry, Tokyo Medical and Dental University, Tokyo, Japan.
Int Dent J. 2018 Apr;68(2):67-76. doi: 10.1111/idj.12320. Epub 2017 May 21.
To review the evidence regarding the mechanisms of silver diamine fluoride (SDF) for arresting caries.
A literature search was conducted using the keywords silver diamine fluoride, and its alternative names, in seven databases: PubMed, Embase and Scopus (English); China National Knowledge Infrastructure (Chinese); Bilioteca Virtual em Saude (Portuguese); Biblioteca Virtual en Salud Espana (Spanish); and Ichushi-Web (Japanese). The titles and abstracts were screened. Full texts were retrieved for publications that studied mechanisms of actions of SDF, including its effects on remineralisation of carious lesions and on cariogenic bacteria.
A total of 1,123 publications were identified. Twenty-nine articles were included and they investigated the effect of SDF on cariogenic bacteria and dental hard tissues. Eleven studies investigated the antibacterial properties of SDF. They found that SDF was bactericidal to cariogenic bacteria, mainly Streptococcus mutans. It inhibited the growth of cariogenic biofilms on teeth. Twenty studies reported the remineralisation of demineralised enamel or dentine by SDF. They found that mineral loss of demineralised enamel and dentine was reduced after SDF treatment. A highly mineralised surface rich in calcium and phosphate was formed on arrested carious lesions. Four studies examined the effect of SDF on dentine collagen. They found that SDF inhibited collagenases (matrix metalloproteinases and cysteine cathepsins) and protected dentine collagen from destruction.
SDF is a bactericidal agent and reduces the growth of cariogenic bacteria. It inhibits demineralisation and promotes the remineralisation of demineralised enamel and dentine. It also hampers degradation of the dentine collagen.
综述评价银胺氟化（SDF）防龋作用机制的相关证据。
通过关键词“silver diamine fluoride”及其别名在 7 个数据库（英文数据库 PubMed、Embase 和 Scopus；中文数据库中国知网；葡萄牙语数据库 Bilioteca Virtual em Saude；西班牙语数据库 Biblioteca Virtual en Salud Espana；和日语数据库 Ichushi-Web）中进行文献检索。筛选标题和摘要。检索研究 SDF 作用机制（包括对龋损再矿化和致龋菌的影响）的出版物全文。
共检索到 1123 篇文献。纳入 29 篇文章，均探讨了 SDF 对致龋菌和牙体硬组织的影响。11 项研究调查了 SDF 的抗菌特性。结果发现，SDF 对致龋菌，主要是变形链球菌具有杀菌作用。它可抑制牙面致龋生物膜的生长。20 项研究报告了 SDF 对脱矿牙釉质或牙本质的再矿化作用。结果发现，经 SDF 处理后，脱矿牙釉质和牙本质的矿物质损失减少。在被抑制的龋损部位形成富含钙和磷的高度矿化表面。4 项研究检查了 SDF 对牙本质胶原的影响。结果发现，SDF 抑制胶原酶（基质金属蛋白酶和半胱氨酸组织蛋白酶），保护牙本质胶原不被破坏。
SDF 是一种杀菌剂，可减少致龋菌的生长。它抑制脱矿作用并促进脱矿牙釉质和牙本质的再矿化。它还可阻止牙本质胶原的降解。
