Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Canada.
School of Public Health, Université de Montréal, Montréal, Canada.
Addiction. 2017 Oct;112(10):1871-1881. doi: 10.1111/add.13876. Epub 2017 Jul 17.
Substance use and binge drinking during early adolescence are associated with neurocognitive abnormalities, mental health problems and an increased risk for future addiction. The trial aims to evaluate the protective effects of an evidence-based substance use prevention programme on the onset of alcohol and drug use in adolescence, as well as on cognitive, mental health and addiction outcomes over 5 years.
Thirty-eight high schools will be recruited, with a final sample of 31 schools assigned to intervention or control conditions (3826 youth). Brief personality-targeted interventions will be delivered to high-risk youth attending intervention schools during the first year of the trial. Control school participants will receive no intervention above what is offered to them in the regular curriculum by their respective schools.
Public/private French and English high schools in Montreal (Canada).
All grade 7 students (12-13 years old) will be invited to participate. High-risk youth will be identified as those scoring one standard deviation or more above the school mean on one of the four personality subscales of the Substance Use Risk Profile Scale (40-45% youth).
Self-reported substance use and mental health symptoms and cognitive functioning measured annually throughout 5 years. Primary outcomes are the onset of substance use disorders at 4 years post-intervention (year 5). Secondary intermediate outcomes are the onset of alcohol and substance use 2 years post-intervention and neuropsychological functions; namely, the protective effects of substance use prevention on cognitive functions generally, and executive functions and reward sensitivity specifically.
This longitudinal, cluster-randomized controlled trial will investigate the impact of a brief personality-targeted intervention program on reducing the onset of addiction 4 years-post intervention. Results will tease apart the developmental sequences of uptake and growth in substance use and cognitive development in adolescence using developmentally sensitive neuropsychological measures.
青少年早期的物质使用和狂饮与神经认知异常、心理健康问题以及未来成瘾的风险增加有关。本试验旨在评估基于证据的物质使用预防计划对青少年期酒精和药物使用的发生以及对 5 年内认知、心理健康和成瘾结果的保护作用。
将招募 38 所高中，最终有 31 所学校被分配到干预组或对照组（3826 名青少年）。在试验的第一年，将向参加干预学校的高风险青少年提供简短的以人格为目标的干预措施。对照组的参与者将不会接受除各自学校常规课程提供的干预措施之外的任何干预措施。
加拿大蒙特利尔的公立/私立法国和英语高中。
所有 7 年级学生（12-13 岁）都将被邀请参加。高风险青少年将被确定为那些在物质使用风险概况量表的四个人格分量表中的一个量表上的得分比学校平均值高出一个标准差或更多的人（40-45%的青少年）。
在 5 年期间每年测量一次自我报告的物质使用和心理健康症状以及认知功能。主要结局是在干预后 4 年（第 5 年）出现物质使用障碍。次要中间结局是在干预后 2 年出现酒精和物质使用以及神经心理功能；即，物质使用预防对认知功能的总体保护作用，特别是对执行功能和奖励敏感性的保护作用。
这项纵向、聚类随机对照试验将研究简短的以人格为目标的干预计划对减少干预后 4 年成瘾发生率的影响。结果将使用发展敏感的神经心理测量方法，梳理青少年期物质使用和认知发展的摄入和增长的发展序列。
