Sun Benjamin C, Lupulescu-Mann Nicoleta, Charlesworth Christina J, Kim Hyunjee, Hartung Daniel M, Deyo Richard A, John McConnell K
Center for Policy Research-Emergency Medicine, Department of Emergency Medicine, Oregon Health and Science University, Portland, OR.
Center for Health Systems Effectiveness, Oregon Health and Science University, Portland, OR.
Acad Emerg Med. 2017 Aug;24(8):905-913. doi: 10.1111/acem.13230. Epub 2017 Jul 26.
Washington State mandated seven hospital "best practices" in July 2012, several of which may affect emergency department (ED) opioid prescribing and provide a policy template for addressing the opioid prescription epidemic. We tested the hypothesis that the mandates would reduce opioid dispensing after an ED visit. We further assessed for a selective effect in patients with prior risky or chronic opioid use.
We performed a retrospective, observational analysis of ED visits by Medicaid fee-for-service beneficiaries in Washington State, between July 1, 2011, and June 30, 2013. We used an interrupted time-series design to control for temporal trends and patient characteristics. The primary outcome was any opioid dispensing within 3 days after an ED visit. The secondary outcome was total morphine milligram equivalents (MMEs) dispensed within 3 days.
We analyzed 266,614 ED visits. Mandates were associated with a small reduction in opioid dispensing after an ED visit (-1.5%, 95% confidence interval [CI] = -2.8% to -0.15%). The mandates were associated with decreased opioid dispensing in 42,496 ED visits by patients with prior risky opioid use behavior (-4.7%, 95% CI = -7.1% to -2.3%) and in 20,238 visits by patients with chronic opioid use (-3.6%, 95% CI = -5.6% to -1.7%). Mandates were not associated with reductions in MMEs per dispense in the overall cohort or in either subgroup.
Washington State best practice mandates were associated with small but nonselective reductions in opioid prescribing rates. States should focus on alternative policies to further reduce opioid dispensing in subgroups of high-risk and chronic users.
华盛顿州于2012年7月强制推行了七项医院“最佳实践”,其中几项可能会影响急诊科(ED)阿片类药物的处方开具,并为应对阿片类药物处方泛滥问题提供政策模板。我们检验了以下假设:这些强制规定将减少急诊就诊后的阿片类药物配药。我们还进一步评估了对有既往高风险或长期阿片类药物使用史患者的选择性影响。
我们对2011年7月1日至2013年6月30日期间华盛顿州医疗补助按服务收费受益人的急诊就诊情况进行了回顾性观察分析。我们采用间断时间序列设计来控制时间趋势和患者特征。主要结局是急诊就诊后3天内的任何阿片类药物配药情况。次要结局是3天内配药的吗啡毫克当量(MME)总量。
我们分析了266,614次急诊就诊情况。这些强制规定与急诊就诊后阿片类药物配药的小幅减少相关(-1.5%,95%置信区间[CI]=-2.8%至-0.15%)。这些强制规定与有既往高风险阿片类药物使用行为患者的42,496次急诊就诊中阿片类药物配药减少相关(-4.7%,95%CI=-7.1%至-2.3%),以及与长期阿片类药物使用患者的20,238次就诊中阿片类药物配药减少相关(-3.6%,95%CI=-5.6%至-1.7%)。这些强制规定与总体队列或任何一个亚组中每次配药的MME减少无关。
华盛顿州的最佳实践强制规定与阿片类药物处方率的小幅但非选择性降低相关。各州应关注替代政策,以进一步减少高风险和长期使用患者亚组中的阿片类药物配药情况。