National Engineering Research Center for Nano-Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
CAS Center of Excellence for Nanoscience, Beijing Engineering Research Center for BioNanotechnology, CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, China.
Small. 2017 Jul;13(27). doi: 10.1002/smll.201700130. Epub 2017 May 23.
Bacterial infections, especially multidrug-resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram-negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility. On Escherichia coli- or Pseudomonas aeruginosa-infected full-thickness skin wounds on rats, the BC-Au-DAPT nanocomposites inhibit bacterial growth and promote wound repair. Thus, the BC-Au-DAPT nanocomposite system is a promising platform for treating superbug-infected wounds.
细菌感染，尤其是多重耐药性细菌感染，是伤口愈合领域日益严重的问题。在此，通过 4,6-二氨基-2-嘧啶硫醇（DAPT）修饰的金纳米粒子（Au-DAPT NPs）对细菌纤维素（BC）进行修饰，将其作为一种敷料（BC-Au-DAPT 纳米复合材料）用于治疗细菌感染的伤口。BC-Au-DAPT 纳米复合材料在抑制革兰氏阴性菌方面比大多数抗生素（头孢唑林/磺胺甲恶唑）具有更好的疗效（以降低最小抑菌浓度来衡量），同时保持出色的物理化学性质，包括吸水性、机械应变和生物相容性。在大鼠的全层皮肤感染大肠杆菌或铜绿假单胞菌的伤口上，BC-Au-DAPT 纳米复合材料能抑制细菌生长并促进伤口修复。因此，BC-Au-DAPT 纳米复合材料体系是治疗超级细菌感染伤口的一种很有前途的平台。
