Curtin Mark, Piggott Robert P, Murphy Evelyn P, Munigangaiah Sudarshan, Baker Joseph F, McCabe John P, Devitt Aiden
Department of Trauma and Orthopaedic Surgery, University College Hospital Galway, Saolta Hospital Group, Galway, Ireland.
Orthop Surg. 2017 May;9(2):145-151. doi: 10.1111/os.12334. Epub 2017 May 24.
Historically, a simple approach centered on palliation was applicable to the majority of patients with metastatic spinal disease. With advances in diagnosis and treatment, a more complicated algorithm has devolved requiring a multidisciplinary approach with institutional commitment and support. We performed a database review including pertinent articles exploring the multidisciplinary management of spinal metastatic disease. The wide variation in clinical presentation and tumor response to treatment necessitates a multidisciplinary approach that integrates the diagnosis and treatment of the cancer, symptom management, and rehabilitation for optimal care of patients with spinal metastases. Advances in the field of radiology have led to earlier and more focused diagnosis of spinal metastasis and acts to guide therapy. Advances in surgical techniques, neurophysiologic monitoring, and anesthetic expertise have allowed surgeons to perform more extensive procedures leading to improved outcomes and reduced morbidity. Radiation oncology input that is essential as external beam radiation therapy can provide significant pain relief. Non-operative measures may include bisphosphonate infusions, management of complications (e.g. hypercalcemia of malignancy), monoclonal antibody infusions, and chemotherapy if indicated in the treatment of the primary malignancy. Input from psychology services is necessary to address the biopsychosocial ramifications of spinal metastasis. Allied health professionals in the form of physiotherapists, social workers, and dieticians also contribute in maximizing patients' quality of life and well-being.
从历史上看,一种以姑息治疗为中心的简单方法适用于大多数转移性脊柱疾病患者。随着诊断和治疗的进展,一种更复杂的算法逐渐形成,需要多学科方法以及机构的投入和支持。我们对数据库进行了回顾,包括探讨脊柱转移性疾病多学科管理的相关文章。临床表现和肿瘤对治疗的反应差异很大,因此需要一种多学科方法,将癌症的诊断和治疗、症状管理以及康复整合起来,以实现对脊柱转移瘤患者的最佳护理。放射学领域的进展已使脊柱转移瘤的诊断更早且更具针对性,并有助于指导治疗。手术技术、神经生理学监测和麻醉专业知识的进步使外科医生能够进行更广泛的手术,从而改善预后并降低发病率。放射肿瘤学的投入至关重要,因为外照射放疗可显著缓解疼痛。非手术措施可能包括双膦酸盐输注、并发症管理(如恶性肿瘤高钙血症)、单克隆抗体输注以及在原发性恶性肿瘤治疗中有指征时进行化疗。心理服务的投入对于解决脊柱转移瘤的生物心理社会影响是必要的。物理治疗师、社会工作者和营养师等专职医疗人员也有助于最大限度地提高患者的生活质量和幸福感。