Sanders Donald B, Guptill Jeffrey T, Aleš Kathy L, Hobson-Webb Lisa D, Jacobus David P, Mahmood Riaz, Massey Janice M, Pittman Melissa M, Prather Kristi, Raja Shruti M, Yow Eric, Juel Vern C
Neuromuscular Section, Department of Neurology, Duke University Medical Center, Box 3403, Durham, North Carolina, 27710, USA.
Jacobus Pharmaceutical Company, Princeton, New Jersey, USA.
Muscle Nerve. 2018 Jan;57(1):136-139. doi: 10.1002/mus.25700. Epub 2017 Jun 6.
We report the reliability of a new measure, the triple-timed up-and-go (3TUG) test, for assessing clinical function in patients with Lambert-Eaton myasthenia (LEM).
Intrarater reproducibility and interrater agreement of the 3TUG test were assessed in 25 control participants, 24 patients with non-LEM neuromuscular disease, and 12 patients with LEM. The coverage probability (CP) method was the primary measure of reproducibility and agreement. The a priori acceptable range was < 20% difference in 3TUG test times and a CP ≥0.90 confirmed agreement.
CP values > 0.90 for intrarater and interrater tests confirmed acceptable reproducibility and agreement for all groups.
The 3TUG test is a quick, noninvasive, and reproducible measure that is easy to perform, measures clinically important weakness in LEM patients, and requires little training. Additional evaluation in a larger number of LEM patients is in progress to validate the 3TUG test as a clinical measure in LEM. Muscle Nerve 57: 136-139, 2017.
我们报告了一种新的测量方法——三次计时起立行走（3TUG）测试，用于评估兰伯特-伊顿肌无力（LEM）患者的临床功能。
在25名对照参与者、24名非LEM神经肌肉疾病患者和12名LEM患者中评估3TUG测试的评分者内再现性和评分者间一致性。覆盖概率（CP）方法是再现性和一致性的主要测量指标。先验可接受范围为3TUG测试时间差异<20%，且CP≥0.90可确认一致性。
评分者内和评分者间测试的CP值>0.90，证实所有组的再现性和一致性均可接受。
3TUG测试是一种快速、无创且可重复的测量方法，易于实施，可测量LEM患者临床上重要的肌无力，且几乎无需培训。目前正在对更多LEM患者进行进一步评估，以验证3TUG测试作为LEM临床测量方法的有效性。《肌肉与神经》57: 136 - 139, 2017年。
