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儿童患者合并全身和胸膜内抗真菌治疗曲霉性脓胸的管理：病例报告。

Management of Aspergillus pleural empyema with combined systemic and intrapleural antifungal therapy in a pediatric patient: Case report.

机构信息

King Faisal Specialist Hospital & Research Centre Pharmaceutical Care Division, Saudi Arabia.

King Faisal Specialist Hospital & Research Centre Surgery Department, Saudi Arabia.

出版信息

J Infect Public Health. 2018 Mar-Apr;11(2):280-282. doi: 10.1016/j.jiph.2017.04.003. Epub 2017 May 22.

DOI:10.1016/j.jiph.2017.04.003
PMID:28545901
Abstract

We present the case of an 8-year-old immunocompromised boy with invasive pulmonary aspergillosis, complicated with pleural empyema and disseminated to the bone and central nervous system (CNS). The patient was treated with combined systemic antifungal agents (voriconazole and caspofungin) and intrapleural instillation of liposomal amphotericin B, in addition to surgical intervention. The treatment was well tolerated and resulted in remarkable clinical and radiological pulmonary improvement.

摘要

我们报告了一例 8 岁免疫功能低下男孩患有侵袭性肺曲霉病，合并脓胸，并播散至骨骼和中枢神经系统（CNS）。患者接受了联合全身抗真菌药物（伏立康唑和卡泊芬净）和胸膜内注射脂质体两性霉素 B 的治疗，此外还进行了手术干预。治疗耐受良好，临床和影像学肺部改善显著。

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