Okumura Ryu, Takeda Kiyoshi
Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Exp Mol Med. 2017 May 26;49(5):e338. doi: 10.1038/emm.2017.20.
The intestine is a unique organ inhabited by a tremendous number of microorganisms. Intestinal epithelial cells greatly contribute to the maintenance of the symbiotic relationship between gut microbiota and the host by constructing mucosal barriers, secreting various immunological mediators and delivering bacterial antigens. Mucosal barriers, including physical barriers and chemical barriers, spatially segregate gut microbiota and the host immune system to avoid unnecessary immune responses to gut microbes, leading to the intestinal inflammation. In addition, various immunological mediators, including cytokines and chemokines, secreted from intestinal epithelial cells stimulated by gut microbiota modulate host immune responses, maintaining a well-balanced relationship between gut microbes and the host immune system. Therefore, impairment of the innate immune functions of intestinal epithelial cells is associated with intestinal inflammation.
肠道是一个独特的器官，栖息着大量微生物。肠道上皮细胞通过构建黏膜屏障、分泌各种免疫介质以及呈递细菌抗原，对维持肠道微生物群与宿主之间的共生关系做出了巨大贡献。黏膜屏障，包括物理屏障和化学屏障，在空间上分隔肠道微生物群和宿主免疫系统，以避免对肠道微生物产生不必要的免疫反应，从而导致肠道炎症。此外，肠道微生物群刺激肠道上皮细胞分泌的各种免疫介质，包括细胞因子和趋化因子，可调节宿主免疫反应，维持肠道微生物与宿主免疫系统之间的平衡关系。因此，肠道上皮细胞固有免疫功能的受损与肠道炎症相关。
Zotero 插件
