Hatakenaka Yuhei, Ninomiya Hitoshi, Billstedt Eva, Fernell Elisabeth, Gillberg Christopher
Kochi Gillberg Neuropsychiatry Centre, Kochi Prefectural Medical and Welfare Center, Kochi, Japan.
Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Neuropsychiatr Dis Treat. 2017 May 10;13:1271-1280. doi: 10.2147/NDT.S132546. eCollection 2017.
Screening for developmental disorders is an important task for Child Health Care. The concept of ESSENCE (early symptomatic syndromes eliciting neurodevelopmental clinical examinations) was created to cover all types of early developmental disorders and the ESSENCE-Questionnaire (ESSENCE-Q containing 12 questions with possible total scores ranging from 0 to 22) was developed as a tool for early detection of these disorders. The aim of this study was to perform a validation study in a public health situation in Japan.
The psychometric properties of the ESSENCE-Q, completed by mothers, public health nurses (PHNs), and psychologists at 18-month (n=143 children) and 36-month (n=149 children) checkups were evaluated in a small city of Japan. Results were validated against clinical ESSENCE diagnoses. Receiver operating characteristic curves were generated and compared by using the area under the curve (AUC). Optimal cutoff values were explored.
At the 18-month checkup, AUC by mothers was 0.72, by PHNs 0.86, and by psychologists 0.82. An optimal cutoff was 3 with a high negative predictive value (NPV). At the 36-month checkup, AUC by mothers was 0.57, by PHNs 0.82, and by psychologists 0.87. Optimal cutoff was 2 with high NPV.
The ESSENCE-Q completed by PHNs and psychologists had good diagnostic validity. The results suggested that almost all children scoring under cutoff would not have any ESSENCE problems/diagnoses.
发育障碍筛查是儿童保健的一项重要任务。“本质”(引发神经发育临床检查的早期症状综合征)概念的提出是为了涵盖所有类型的早期发育障碍,并且开发了“本质问卷”(ESSENCE-Q,包含12个问题,总分范围为0至22分)作为这些障碍早期检测的工具。本研究的目的是在日本的公共卫生环境中进行一项验证研究。
在日本的一个小城市,对母亲、公共卫生护士(PHN)和心理学家在18个月(n = 143名儿童)和36个月(n = 149名儿童)体检时完成的ESSENCE-Q的心理测量特性进行了评估。结果与临床“本质”诊断进行了验证。生成了受试者操作特征曲线,并使用曲线下面积(AUC)进行比较。探索了最佳截断值。
在18个月体检时,母亲完成的AUC为0.72,公共卫生护士为0.86,心理学家为0.82。最佳截断值为3,具有较高的阴性预测值(NPV)。在36个月体检时,母亲完成的AUC为0.57,公共卫生护士为0.82,心理学家为0.87。最佳截断值为2,具有较高的NPV。
由公共卫生护士和心理学家完成的ESSENCE-Q具有良好的诊断效度。结果表明,几乎所有得分低于截断值的儿童都不会有任何“本质”问题/诊断。