PAQR3抑制食管癌细胞的增殖和肿瘤发生。
PAQR3 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer Cells.
作者信息
Zhou Fang, Wang Shunchang, Wang Jianjun
出版信息
Oncol Res. 2017 May 24;25(5):663-671. doi: 10.3727/096504016X14761384026719.
Progestin and adipoQ receptor family member III (PAQR3), a member of the PAQR family, is frequently downregulated in different types of human cancer. However, its expression and functions in esophageal cancer are still unknown. This study aimed to explore the expression of PAQR3 in esophageal cancer cell lines and to investigate the role of PAQR3 in the development of esophageal cancer. Our data showed that PAQR3 is expressed in low amounts in human esophageal cancer cell lines. Overexpression of PAQR3 significantly suppressed the proliferation, migration, and invasion of esophageal cancer cells. In addition, overexpression of PAQR3 downregulated the protein expression levels of RAF1, p-MEK1, and p-ERK1/2 in esophageal cancer cells. Furthermore, overexpression of PAQR3 attenuated the tumor growth in a tumor xenograft model. In conclusion, we demonstrated that overexpression of PAQR3 suppresses cell proliferation, migration, and invasion in esophageal cancer in vitro and in vivo. Therefore, PAQR3 may act as a therapeutic target for human esophageal cancer.
孕激素和脂联素受体家族成员III（PAQR3）是PAQR家族的一员，在不同类型的人类癌症中经常下调。然而，其在食管癌中的表达和功能仍不清楚。本研究旨在探讨PAQR3在食管癌细胞系中的表达，并研究PAQR3在食管癌发生发展中的作用。我们的数据显示，PAQR3在人食管癌细胞系中的表达量较低。PAQR3的过表达显著抑制了食管癌细胞的增殖、迁移和侵袭。此外，PAQR3的过表达下调了食管癌细胞中RAF1、p-MEK1和p-ERK1/2的蛋白表达水平。此外，PAQR3的过表达减弱了肿瘤异种移植模型中的肿瘤生长。总之，我们证明PAQR3的过表达在体外和体内均抑制食管癌细胞的增殖、迁移和侵袭。因此，PAQR3可能作为人类食管癌的治疗靶点。
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