Lin Jinle, Zhang Wenwu, Wang Lijun, Tian Fang
Department of Emergency and Critical Care Medicine, Baoan Hospital, Nanfang Medical University, Shenzhen, Guangdong, China.
Department of Critical Care Medicine, Baoan Hospital, Nanfang Medical University, Shenzhen, Guangdong, China.
J Clin Lab Anal. 2018 Feb;32(2). doi: 10.1002/jcla.22262. Epub 2017 May 26.
Acute respiratory distress syndrome (ARDS) is a critical condition characterized by bilateral pulmonary infiltrates and severe hypoxemia. This study aimed to evaluate the diagnostic and prognostic values of Club cell protein 16 (CC16) in critical care patients with ARDS.
In this retrospective observational study, 83 patients with ARDS and 129 non-ARDS patients on ICU admission were enrolled. The differences in serum CC16 and other laboratory indicators between two groups were analyzed. The sensitivity, specificity, positive and negative predictive values, and accuracy of CC16 as a diagnostic marker on ICU admission were determined by receiver operating characteristic (ROC) curve analysis. The correlation between serum CC16 levels and the severity of ARDS as quantified by PaO /FiO ratio were further assessed. CC16 levels were compared between survivors and non-survivors. The relationships between CC16 levels and duration of ICU and hospitalization were evaluated.
The serum CC16 levels in ARDS patients were significantly higher than that in non-ARDS patients (54.44±19.62 vs 24.13±12.32 ng/mL, P=.001). ROC analysis showed that the sensitivity, specificity, positive predictive value, and negative predictive value were 90.4%, 79.8%, 74.2%, and 92.8%, respectively, when the cut-off value was set at 33.3 ng/mL. CC16 levels were correlated with the severity of ARDS. The serum CC16 levels were significantly greater in non-survivors than in survivors from the ARDS group. CC16 levels were associated with ICU stay but not hospital stay.
CC16 may serve as a diagnostic and stratification marker for ARDS. However, it provided limited prognostic information for ARDS.
急性呼吸窘迫综合征（ARDS）是一种以双侧肺部浸润和严重低氧血症为特征的危急病症。本研究旨在评估克拉拉细胞蛋白16（CC16）在ARDS重症监护患者中的诊断和预后价值。
在这项回顾性观察研究中，纳入了83例ARDS患者和129例入住ICU时的非ARDS患者。分析了两组患者血清CC16和其他实验室指标的差异。通过受试者工作特征（ROC）曲线分析确定CC16作为入住ICU时诊断标志物的敏感性、特异性、阳性和阴性预测值以及准确性。进一步评估血清CC16水平与通过PaO₂/FiO₂比值量化的ARDS严重程度之间的相关性。比较了幸存者和非幸存者的CC16水平。评估了CC16水平与ICU住院时间和住院时间之间的关系。
ARDS患者的血清CC16水平显著高于非ARDS患者（54.44±19.62 vs 24.13±12.32 ng/mL，P = 0.001）。ROC分析显示，当临界值设定为33.3 ng/mL时，敏感性、特异性、阳性预测值和阴性预测值分别为90.4%、79.8%、74.2%和92.8%。CC16水平与ARDS的严重程度相关。ARDS组中非幸存者的血清CC16水平显著高于幸存者。CC16水平与ICU住院时间相关，但与住院时间无关。
CC16可能作为ARDS的诊断和分层标志物。然而，它为ARDS提供的预后信息有限。
