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弥漫性大B细胞淋巴瘤中白细胞亚群的预后意义

Prognostic implication of leucocyte subpopulations in diffuse large B-cell lymphoma.

作者信息

Han Xiao, Ruan Jing, Zhang Wei, Zhou Daobin, Xu Dongsheng, Pei Qiang, Ouyang Mingqi, Zuo Mengxuan

机构信息

Department of Hematology, Peking Union Medical College Hospital, Beijing, China 100730.

Department of Hematopathology, CBLPath, Sonic Healthcare, Rye Brook, NY 10573, USA.

出版信息

Oncotarget. 2017 Jul 18;8(29):47790-47800. doi: 10.18632/oncotarget.17830.

DOI:10.18632/oncotarget.17830
PMID:28548962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5564605/
Abstract

BACKGROUND

Recent studies have suggested that variables related to host adaptive immunity and the tumor microenvironment may predict the outcome in patients with non-Hodgkin's lymphoma. This study was undertaken to determine the prognostic value of peripheral blood leucocyte subpopulations in diffuse large-B-cell lymphoma patients.

METHODS

We prospectively analyzed the 16 leukocyte subpopulations using Cytodiff flow cytometric technique in a cohort of 45 diffuse large-B-cell lymphoma patients at a single institution between February and December 2014. The Cox proportional hazards model was used to evaluate prognostic factors for overall survival and progression free survival.

RESULTS

Diffuse large-B-cell lymphoma patients had decreased cytotoxic and non-cytotoxic NK&T cells as well as increased CD16+ monocytes, CD16- monocytes and mature neutrophils. The decreased CD16- monocyte/CD16+ monocyte ratio and increased mature neutrophil/cytotoxic NK&T cell ratio were related to poor progression-free and overall survival outcome in single and multivariate analysis. The co-constructed model using International Prognostic Index and mature neutrophil/cytotoxic NK&T cell ratio can also help discriminate the clinical outcome.

CONCLUSIONS

The decreased CD16-monocyte/CD16+monocyte ratio and increased mature neutrophil/cytotoxic NK&T cell ratio predict poor prognosis in diffuse large-B-cell lymphoma patients. This finding provides a strong rationale for the study of cellular immunotherapy in B-cell lymphoma.

摘要

背景

近期研究表明，与宿主适应性免疫和肿瘤微环境相关的变量可能预测非霍奇金淋巴瘤患者的预后。本研究旨在确定外周血白细胞亚群在弥漫性大B细胞淋巴瘤患者中的预后价值。

方法

我们于2014年2月至12月在一家机构对45例弥漫性大B细胞淋巴瘤患者，采用细胞分化流式细胞术对16种白细胞亚群进行了前瞻性分析。采用Cox比例风险模型评估总生存和无进展生存的预后因素。

结果

弥漫性大B细胞淋巴瘤患者的细胞毒性和非细胞毒性NK&T细胞减少，而CD16+单核细胞、CD16-单核细胞和成熟中性粒细胞增加。在单因素和多因素分析中，CD16-单核细胞/CD16+单核细胞比例降低和成熟中性粒细胞/细胞毒性NK&T细胞比例增加与无进展生存期和总生存期较差相关。使用国际预后指数和成熟中性粒细胞/细胞毒性NK&T细胞比例共同构建的模型也有助于区分临床结局。

结论

CD16-单核细胞/CD16+单核细胞比例降低和成熟中性粒细胞/细胞毒性NK&T细胞比例增加预示弥漫性大B细胞淋巴瘤患者预后不良。这一发现为B细胞淋巴瘤细胞免疫治疗的研究提供了有力依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8106/5564605/d1c4006e15e0/oncotarget-08-47790-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8106/5564605/ed4536b1e36d/oncotarget-08-47790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8106/5564605/5a8d4be6da36/oncotarget-08-47790-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8106/5564605/d1c4006e15e0/oncotarget-08-47790-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8106/5564605/ed4536b1e36d/oncotarget-08-47790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8106/5564605/5a8d4be6da36/oncotarget-08-47790-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8106/5564605/d1c4006e15e0/oncotarget-08-47790-g003.jpg

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