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基于基线 CD16-/CD16+单核细胞比率降低预测新诊断 T 细胞淋巴瘤患者的预后更差。

Predicting worse survival for newly diagnosed T cell lymphoma based on the decreased baseline CD16-/CD16 + monocyte ratio.

机构信息

Department of Hematology, Peking Union Medical College Hospital, Beijing, 100730, China.

出版信息

Sci Rep. 2020 May 8;10(1):7757. doi: 10.1038/s41598-020-64579-z.

DOI:10.1038/s41598-020-64579-z
PMID:32385351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7211003/
Abstract

T cell non-Hodgkin lymphoma (T-NHL) is highly invasive and heterogeneous without accurate prognosis prediction. We proposed peripheral CD16-/CD16 + monocytes the additional indicators for T-NHL prognosis. We prospectively recruited 31 T-NHL patients without previous treatment. The CD16-/CD16 + monocyte ratio before chemotherapy was calculated and regular follow up was performed to calculate prognostic prediction value. Tumor associated macrophages (TAM) in tumor tissue were counted and transcriptome sequencing of CD16- and CD16 + monocytes was applied to explore potential mechanisms. We found that T-NHL patients had higher ratio of total monocytes especially the CD16 + monocytes along with a decreased ratio of CD16-/CD16 + monocytes, compared to the health control. The 1-year overall survival rate was 0.492 and 0.755 for CD16- monocyte/CD16 + monocyte ratio of <11 and ≥11(p < 0.05), respectively. The peripheral CD16-/CD16 + monocyte ratio was significantly relevant with the pathological CD68/CD206 macrophage ratio. The differently expressed genes in CD16- and CD16 + monocytes from T-NHL patients were mainly involved in signaling molecules related to tumor microenvironment. Pro-tumor genes were identified in monocyte subsets especially in CD16 + monocytes. In conclusion, the ratio of peripheral CD16-/CD16 + monocyte helps to stratify the prognosis of T-NHL. The relatively increased CD16 + monocytes may contribute to the pro-tumor microenvironment of T-NHL.

摘要

T 细胞非霍奇金淋巴瘤（T-NHL）侵袭性高，异质性强，缺乏准确的预后预测。我们提出外周血 CD16-/CD16+单核细胞是 T-NHL 预后的附加指标。我们前瞻性招募了 31 例未经治疗的 T-NHL 患者。计算化疗前 CD16-/CD16+单核细胞比值，并进行常规随访，以计算预后预测价值。计数肿瘤组织中的肿瘤相关巨噬细胞（TAM），并对 CD16-和 CD16+单核细胞进行转录组测序，以探讨潜在的机制。我们发现，与健康对照组相比，T-NHL 患者总单核细胞比例较高，尤其是 CD16+单核细胞比例较高，而 CD16-/CD16+单核细胞比例降低。CD16-单核细胞/CD16+单核细胞比值<11 和≥11 的患者 1 年总生存率分别为 0.492 和 0.755（p<0.05）。外周血 CD16-/CD16+单核细胞比值与病理 CD68/CD206 巨噬细胞比值显著相关。T-NHL 患者 CD16-和 CD16+单核细胞中差异表达的基因主要涉及与肿瘤微环境相关的信号分子。在单核细胞亚群中特别是在 CD16+单核细胞中鉴定出促肿瘤基因。总之，外周血 CD16-/CD16+单核细胞比值有助于分层 T-NHL 的预后。相对增加的 CD16+单核细胞可能有助于 T-NHL 的促肿瘤微环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/61999e9dc09b/41598_2020_64579_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/f304a40c4774/41598_2020_64579_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/124ac4f5b641/41598_2020_64579_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/32b807621d6d/41598_2020_64579_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/b3408f25fa59/41598_2020_64579_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/61999e9dc09b/41598_2020_64579_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/f304a40c4774/41598_2020_64579_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/124ac4f5b641/41598_2020_64579_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/32b807621d6d/41598_2020_64579_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/b3408f25fa59/41598_2020_64579_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3164/7211003/61999e9dc09b/41598_2020_64579_Fig5_HTML.jpg

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