Li H
Cancer Institute, China University of Medical Sciences, Shenyang.
Zhonghua Zhong Liu Za Zhi. 1988 Nov;10(6):421-3.
The invasive and metastatic behavior of SY86B human gastric carcinoma in nude mice were further studied. The results showed that this human cancer strain had a relatively high spontaneous metastatic rate (68.4%). The metastasis was related to the invasiveness of the transplanted tumor and tumor-bearing time. Since the metastasis developed from 2nd to 9th passages, it was considered that this model had a stable metastatic tendency. It was observed that the genetic background, age and sex difference of the recipient nude mice may not be associated with the metastasis. Aside from the high transplantable rate (100%) and spontaneous metastatic rate (68.4%), SY86B human gastric carcinoma strain still maintains the morphologic, immunologic, genetic and ultrastructural characteristics of the original tumor. All these make it a useful means in the study of diagnosis and treatment of cancer metastasis.
进一步研究了SY86B人胃癌在裸鼠中的侵袭和转移行为。结果显示，这种人类癌株具有相对较高的自发转移率（68.4%）。转移与移植瘤的侵袭性和荷瘤时间有关。由于转移在第2代至第9代出现，因此认为该模型具有稳定的转移倾向。观察到受体裸鼠的遗传背景、年龄和性别差异可能与转移无关。除了高移植率（100%）和自发转移率（68.4%）外，SY86B人胃癌株仍保留了原发肿瘤的形态学、免疫学、遗传学和超微结构特征。所有这些使其成为研究癌症转移诊断和治疗的有用手段。
