Li H, Zhang Y C, Tsuchihashi Y
Cancer Institute, China Medical University, Liaoning.
Jpn J Cancer Res. 1988 Jun;79(6):750-6. doi: 10.1111/j.1349-7006.1988.tb02232.x.
A moderately differentiated tubular adenocarcinoma of human stomach, named SY86B, was successfully transplanted subcutaneously to nude mice of different genetic backgrounds (BALB/CA/PBI-nu, C57BL/6J.615/PBI-nu and ICR.BALB/CA/PBI-nu). The tumor has been passaged for 13 generations and the transplantability was 100%. The SY86B cells retained the capacity of invasive and metastatic growth in the nude mice and showed a high rate of metastasis to the regional lymph nodes and to such distant organs as the lungs, liver and pancreas. The overall rate of metastasis was 77.7%. The species of the nude mice, their age and sex apparently did not significantly affect the occurrence of metastasis. Tumor-bearing time and the aggressive character of the tumor cells themselves appeared important for the genesis of metastasis. This experimental model can provide a new approach to basic and clinical studies of cancer metastasis.
一种名为SY86B的人胃中度分化管状腺癌成功皮下移植到不同遗传背景的裸鼠（BALB/CA/PBI-nu、C57BL/6J.615/PBI-nu和ICR.BALB/CA/PBI-nu）体内。该肿瘤已传代13代，移植成功率为100%。SY86B细胞在裸鼠体内保留了侵袭性和转移性生长能力，向区域淋巴结以及肺、肝和胰腺等远处器官的转移率较高。总体转移率为77.7%。裸鼠的种类、年龄和性别显然对转移的发生没有显著影响。荷瘤时间和肿瘤细胞本身的侵袭性特征似乎对转移的发生很重要。该实验模型可为癌症转移的基础和临床研究提供一种新方法。
