Wei S M
Beijing Institute for Cancer Research.
Zhonghua Zhong Liu Za Zhi. 1992 Jul;14(4):257-60.
A monoclonal antibody (mAb) A12 against gastric cancer was prepared in immuno-reconstituted nude mice from human ductal adenocarcinoma of stomach, Sy86B. mAb A12 could react with the majority of gastric cancer tissues (24/27-88.9%) but only cross react with a few normal tissues tested. The corresponding antigen of mAb A12 (antigen A12) was expressed at higher levels and usually in more than 50% of the cancer cells. mAb A12 may be a valid preparation in targeting therapy of gastric cancer. Preliminary analysis of antigen A12 showed that it is a oncofetal antigen probably of glycolipid or glycoprotein in nature.
用源自人胃导管腺癌Sy86B的免疫重建裸鼠制备了一种抗胃癌的单克隆抗体（mAb）A12。mAb A12能与大多数胃癌组织发生反应（24/27，88.9%），但与所检测的少数正常组织仅有交叉反应。mAb A12的相应抗原（抗原A12）表达水平较高，通常在超过50%的癌细胞中表达。mAb A12可能是胃癌靶向治疗中的一种有效制剂。对抗原A12的初步分析表明，它可能是一种本质上为糖脂或糖蛋白的癌胚抗原。
