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可转座噬菌体、DNA 重组与转移。

Transposable phages, DNA reorganization and transfer.

机构信息

Génétique et Physiologie Bactérienne, Université Libre de Bruxelles, IBMM-DBM, 12 Rue des Professeurs Jeneer et Brachet, B 6041 Gosselies, Belgium.

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 E. 57th St., Chicago, IL 60637, USA.

出版信息

Curr Opin Microbiol. 2017 Aug;38:88-94. doi: 10.1016/j.mib.2017.04.009. Epub 2017 May 25.

Abstract

Transposable bacteriophages have long been known to necessarily and randomly integrate their DNA in their host genome, where they amplify by successive rounds of replicative transposition, profoundly reorganizing that genome. As a result of such transposition, a conjugative element (plasmid or genomic island), can either become integrated in the chromosome or receive chromosome segments, which can then be transferred to new hosts by conjugation. In recent years, more and more transposable phages have been isolated or detected by sequence similarity searches in a wide range of bacteria, supporting the idea that this mode of HGT may be pervasive in natural bacterial populations.

摘要

转座噬菌体长期以来一直被认为必然且随机地将其 DNA 整合到宿主基因组中,在那里它们通过连续的复制转座循环扩增,从而深刻地重组该基因组。由于这种转座作用,一个可移动元件(质粒或基因组岛)可以整合到染色体中,也可以接收染色体片段,然后通过接合将这些片段转移到新的宿主中。近年来,通过对广泛的细菌进行序列相似性搜索,越来越多的可移动噬菌体被分离或检测到,这支持了这种 HGT 模式可能在自然细菌群体中普遍存在的观点。

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