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探索东南亚地区神经囊尾蚴病所致近期发作性癫痫负担的必要性及挑战,重点关注马来西亚的情况。

Needs of exploring the burden of recent onset seizures due to neurocysticercosis and challenges in southeast Asia focusing on scenario in Malaysia.

作者信息

Sahu Priyadarshi S, Lim Yvonne A L, Mahmud Rohela, Somanath Sushela D, Tan Chong T, Ramachandran C P

机构信息

Division of Pathology, School of Medicine, International Medical University, 57000 Kuala Lumpur, Malaysia.

Department of Parasitology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

Asian Pac J Trop Med. 2017 Apr;10(4):332-340. doi: 10.1016/j.apjtm.2017.03.024. Epub 2017 Apr 7.

Abstract

Seizures due to neurocysticercosis (NCC) is a neglected human-to-human transmitted disorder and an emerging problem worldwide. A substantial portion of recent onset seizures is known to be attributed to NCC in Taenia solium (T. solium) endemic areas where populations which neither raise pigs nor eat pig meat are also at risk. High prevalence of NCC causing epilepsy has been reported in the underdeveloped areas of Southeast Asia (SEA) however, only fragmentary information on its incidence is available in countries like Malaysia. In Malaysia T. solium infection was previously thought to be infrequent due to Muslim population majority and the religious prohibition of consuming pork, but it is not totally absent. There is an evident lack of knowledge and awareness of the actual burden, routes of transmission, and the impact of NCC in this region. The problem is assumed to be more prevalent particularly in cities because of the frequent inflow of possibly T. solium infected individuals or carriers among those who migrate from neighboring endemic countries to Malaysia. The issue of imported cases that are likely to be emerging in Malaysia is highlighted here. An accurate quantification of regional burdens of epilepsy due to NCC in Malaysia is warranted considering the disease emergence in its neighboring countries. It is suggested that the importance of NCC be recognized through quantification of its burden, and also to collect epidemiological data for its subsequent elimination in line of World Health Organization's mission for control of cysticercosis as a neglected tropical disease. In this review the need as well as a strategy for neuro-care center screening of epilepsy cases, and various issues with possible explanations are discussed. It is also proposed that NCC be declared as a reportable disease which is one of the eradicable public health problems in SEA.

摘要

神经囊尾蚴病(NCC)所致癫痫是一种被忽视的人传人疾病,在全球范围内日益凸显。在猪带绦虫(T. solium)流行地区,近期发作的癫痫中有很大一部分归因于NCC,在这些地区,既不养猪也不吃猪肉的人群也有感染风险。东南亚(SEA)欠发达地区报告了NCC导致癫痫的高患病率,然而,在马来西亚等国家,关于其发病率的信息却支离破碎。在马来西亚,由于穆斯林人口占多数以及宗教上禁止食用猪肉,以前认为猪带绦虫感染并不常见,但并非完全不存在。该地区明显缺乏对NCC实际负担、传播途径及其影响的了解和认识。由于从邻国迁移到马来西亚的人群中可能有猪带绦虫感染者或携带者频繁流入,这个问题在城市中可能更为普遍。这里强调了马来西亚可能出现的输入性病例问题。考虑到邻国出现的这种疾病,有必要准确量化马来西亚因NCC导致的癫痫的区域负担。建议通过量化NCC的负担来认识其重要性,并按照世界卫生组织控制囊尾蚴病这一被忽视热带病的使命,收集流行病学数据以便后续消除该病。在这篇综述中,讨论了神经护理中心对癫痫病例进行筛查的必要性和策略,以及各种可能的解释问题。还提议将NCC宣布为应报告疾病,这是东南亚可根除的公共卫生问题之一。

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