Çorbacıoğlu Şeref Kerem, Akıncı Emine, Çevik Yunsur, Aytar Halit, Öncül Mehmet Veysel, Akkan Sedat, Uzunosmanoğlu Hüseyin
Kecioren Training and Research Hospital, Department of Emergency Medicine, Ankara, Turkey.
Kecioren Training and Research Hospital, Department of Emergency Medicine, Ankara, Turkey.
Am J Emerg Med. 2017 Nov;35(11):1662-1665. doi: 10.1016/j.ajem.2017.05.034. Epub 2017 May 22.
The study aimed to detect whether modified Valsalva maneuver (VM) is more effective than the standard VM in terminating paroxysmal supraventricular tachycardia (PSVT).
This randomized controlled trial was conducted in the emergency department of a training and research hospital between Dec. 1, 2015 and Dec. 31, 2016. Participants were divided into two groups, randomly assigned standard VM or modified VM, as the first treatment with two-dimensional permutation blocks; in the order of arrival of the patients. In both groups; the determined procedure for standard or modified VM was repeated up to three times in patients whose PSVT did not convert to sinus rhythm. In both groups; if the maneuver was unsuccessful after three attempts, anti-arrhythmic medication was administered. The primary outcome was defined to compare the success rate of achieving sinus rhythm after standard VM or modified VM.
Fifty-six patients were randomized to modified or standard VM with 28 patients in each treatment arm. Three of 28 patients (10.7%) in VM group and 12 of 28 patients (42.9%) in modified VM group were returned to sinus rhythm after intervention (p=0.007). The number of patients who needed rescue treatment was lower in the modified VM group - 16 (57.1%) of 28 versus 25 (89.3%) of 28 in the standard VM group (p=0.007).
This study suggests that modified VM therapy was more effective than standard VM for terminating PSVT. The modified VM therapy also indirectly reduced the need for anti-arrhythmic medication and indirectly caused fewer side effects.
本研究旨在检测改良瓦尔萨尔瓦动作(VM)在终止阵发性室上性心动过速(PSVT)方面是否比标准VM更有效。
本随机对照试验于2015年12月1日至2016年12月31日在一家培训和研究医院的急诊科进行。参与者被分为两组,随机分配接受标准VM或改良VM,作为二维排列块的首次治疗;按照患者到达的顺序。在两组中,如果PSVT未转为窦性心律,标准或改良VM的确定程序在患者中重复进行多达三次。在两组中,如果三次尝试后动作未成功,则给予抗心律失常药物。主要结局定义为比较标准VM或改良VM后实现窦性心律的成功率。
56例患者被随机分为改良或标准VM组,每个治疗组28例患者。VM组28例患者中有3例(10.7%),改良VM组28例患者中有12例(42.9%)在干预后恢复窦性心律(p=0.007)。改良VM组需要抢救治疗的患者数量较少——28例中有16例(57.1%),而标准VM组28例中有25例(89.3%)(p=0.007)。
本研究表明,改良VM疗法在终止PSVT方面比标准VM更有效。改良VM疗法还间接减少了对抗心律失常药物的需求,并间接导致较少的副作用。