Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, P. R. China.
Center of Super-Diamond and Advanced Films (COSDAF) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, P. R. China.
Small. 2019 Sep;15(38):e1903121. doi: 10.1002/smll.201903121. Epub 2019 Aug 5.
The combination of diagnostic and therapeutic functions in a single theranostic nanoagent generally requires the integration of multi-ingredients. Herein, a cytotoxic near-infrared (NIR) dye (IR-797) and its nanoassembly are reported for multifunctional cancer theranostics. The hydrophobic IR-797 molecules are self-assembled into nanoparticles, which are further modified with an amphiphilic polymer (C18PMH-PEG5000) on the surface. The prepared PEG-IR-797 nanoparticles (PEG-IR-797 NPs) possess inherent cytotoxicity from the IR-797 dye and work as a chemotherapeutic drug which induces apoptosis of cancer cells. The IR-797 NPs are found to have an ultrahigh mass extinction coefficient (444.3 L g cm at 797 nm and 385.9 L g cm at 808 nm) beyond all reported organic nanomaterials (<40 L g cm ) for superior photothermal therapy (PTT). In addition, IR-797 shows some aggregation-induced-emission (AIE) properties. Combining the merits of good NIR absorption, high photothermal energy conversion efficiency, and AIE, makes the PEG-IR-797 NPs useful for multimodal NIR AIE fluorescence, photoacoustic, and thermal imaging-guided therapy. The research exhibits the possibility of using a single ingredient and entity to perform multimodal NIR fluorescence, photoacoustic, and thermal imaging-guided chemo-/photothermal combination therapy, which may trigger wide interest from the fields of nanomedicine and medicinal chemistry to explore multifunctional theranostic organic molecules.
在单个治疗诊断纳米制剂中结合诊断和治疗功能通常需要整合多种成分。本文报道了一种具有细胞毒性的近红外（NIR）染料（IR-797）及其纳米组装体，用于多功能癌症治疗诊断。疏水性的 IR-797 分子自组装成纳米颗粒，然后在表面进一步用两亲聚合物（C18PMH-PEG5000）修饰。所制备的 PEG-IR-797 纳米颗粒（PEG-IR-797 NPs）具有源自 IR-797 染料的固有细胞毒性，并作为一种化学治疗药物，诱导癌细胞凋亡。IR-797 NPs 具有超高的质量消光系数（在 797nm 处为 444.3 L g cm，在 808nm 处为 385.9 L g cm，超过所有报道的有机纳米材料（<40 L g cm），可用于优异的光热治疗（PTT）。此外，IR-797 表现出一些聚集诱导发光（AIE）特性。结合良好的近红外吸收、高光热能量转换效率和 AIE 的优点，使 PEG-IR-797 NPs 可用于多模态近红外 AIE 荧光、光声和热成像引导治疗。该研究展示了使用单一成分和实体进行多模态近红外荧光、光声和热成像引导化学/光热联合治疗的可能性，这可能会引发纳米医学和药物化学领域的广泛兴趣，以探索多功能治疗诊断有机分子。
