Gera D N, Shah M K, Ghodela V A, Kute V B, Trivedi H L
Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
Indian J Nephrol. 2017 May-Jun;27(3):228-230. doi: 10.4103/0971-4065.200516.
Well-recognized association between HIV 1 infection and collapsing glomerulopathy (CG) raises the possibility that intrarenal infection by other viruses may also contribute to the development of this lesion in native or post-transplant kidneys. There is evidence in literature about association of these lesions with cytomegalovirus, Epstein-Barr virus, hepatitis C virus, and parvovirus B19 infections. Here, we present a case report of post-transplant BK virus nephropathy in a male child who was found to have CG in subsequent biopsy 2 months later. His renal function and proteinuria were stabilized on elimination of viremia.
人类免疫缺陷病毒1型（HIV 1）感染与塌陷性肾小球病（CG）之间已被充分认识到的关联，增加了一种可能性，即其他病毒的肾内感染也可能导致原发性或移植后肾脏中这种病变的发生。文献中有证据表明这些病变与巨细胞病毒、爱泼斯坦-巴尔病毒、丙型肝炎病毒和细小病毒B19感染有关。在此，我们报告一例男性儿童移植后BK病毒肾病的病例，该患儿在2个月后的后续活检中被发现患有CG。在病毒血症消除后，他的肾功能和蛋白尿得到了稳定。
